Evidence map›Paper›PMID 40133071›Full record

ArticleJournal of the American Chemical Society2025

Nitric Oxide Inhibition of Glycyl Radical Enzymes and Their Activases.

Juan Carlos Cáceres, Nathan G Michellys, Brandon L Greene

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Juan Carlos CáceresInterdisciplinary Program in Quantitative Biosciences, University of California Santa Barbara, Santa Barbara, California 93106, United States.
Nathan G MichellysDepartment of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, United States.
Brandon L GreeneInterdisciplinary Program in Quantitative Biosciences, University of California Santa Barbara, Santa Barbara, California 93106, United States.ORCID 0000-0001-6981-5900

Funding

Regulation and maintenance of thiyl radicals in enzyme catalysis and protein degradationR35GM154993 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Brandon Greene · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM154993
6 · The paper itself

Abstract

Innate immune response cells produce high concentrations of the free radical nitric oxide (NO) in response to pathogen infection. The antimicrobial properties of NO include nonspecific damage to essential biomolecules and specific inactivation of enzymes central to aerobic metabolism. However, the molecular targets of NO in anaerobic metabolism are less understood. Here, we demonstrate that the

Indexed as

Escherichia coliNitric OxideAcetyltransferasesElectron Spin Resonance SpectroscopyFree RadicalsAcetyltransferasesFree RadicalsNitric Oxidepyruvate formate-lyase activating enzyme

Identifiers

PMID40133071
PMCPMC11987019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.