ArticleBMJ open2025
Optimal cut-off points for waist circumference in the definition of metabolic syndrome: a cross-sectional study in rural Bangladesh.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Lean, Non-Autoimmune Young-Onset Diabetes in Bangladesh: A Metabolically Obese Phenotype With Disproportionate Insulin Secretory Defect.Endocrinology, diabetes & metabolism · 2026Article
- Diverse and rare candidate MODY gene variants were identified in one-fifth of a Bangladeshi cohort with nonobese, nonautoimmune youth-onset diabetes.Scientific reports · 2026Article
- Associations between body composition and physical performance in Chinese male adults: a cross-sectional study.Frontiers in public health · 2026Article
- Early-Onset Type 2 Diabetes in Bangladesh: National Estimates and Risk Correlates.AACE endocrinology and diabetesArticle
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Authors and funding
12 authors.
Funding
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Abstract
objectiveTo determine optimal waist circumference (WC) cut-off points for identifying metabolic syndrome (MetS) in Bangladeshi adults, with the aim of enhancing diagnostic accuracy specific to this population.
designCross-sectional analysis.
settingRural community in Chandra, Bangladesh.
participantsA total of 2293 adults aged 20 years and older. PRIMARY AND SECONDARY OUTCOME MEASURES: MetS was defined using the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Receiver operating characteristic (ROC) curves and Youden's Index were used to identify WC cut-off points that maximised sensitivity and specificity for diagnosing MetS. Restricted cubic spline regression was employed to explore the non-linear relationship between WC and MetS risk.
resultsThe optimal WC cut-off points for predicting MetS were 90 cm for men (sensitivity 55.2%, specificity 94.3%, OR 12.5, 95% CI 8.6 to 18.0) and 80 cm for women (sensitivity 86.7%, specificity 71.9%, OR 15.6, 95% CI 11.4 to 21.3). The area under the ROC curve was 0.819 for men and 0.827 for women. Non-linear analysis indicated a significant increase in MetS risk beyond these thresholds, with a steeper risk gradient observed in men.
conclusionsThis study establishes WC cut-off points of 90 cm for men and 80 cm for women as optimal for diagnosing MetS in Bangladeshi adults, underscoring the necessity of population-specific diagnostic criteria to improve early detection and management.
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