ArticleOpen biology2025
Sperm-borne mRNAs: potential roles in zygote genome activation and epigenetic inheritance.
Article in Open biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Nrf2 Levels in Human Semen and Spermatozoa: Association with FInternational journal of molecular sciences · 2026Article
- Pan-organ poly(A) atlas reveals a post-transcriptional regulatory layer independent of RNA abundance.Nature communications · 2026Article
- Sperm TLR2/1 activation modulates the paternal RNA cargo and enhances bovine embryonic development.Frontiers in physiology · 2026Article
- A father's legacy: the sperm epigenome, preimplantation development, and paternal environment.Epigenomics · 2025Review
- Expression of miRNAs Associated With Embryo Development and DNA Damage Response in Porcine Embryos.Molecular reproduction and development · 2025Article
- Paternal Cocaine Exposure and Its Testicular Legacy: Epigenetic, Physiological, and Intergenerational Consequences.Biology · 2025Review
- Rescuing Fertilization Failure in ICSI: A Narrative Review of Calcium Ionophore Activation, PLCζ Testing, and Embryo Morphokinetics.Biomedicines · 2025Review
- Sperm-Derived Dysfunction of Human Embryos: Molecular Mechanisms and Clinical Resolution.International journal of molecular sciences · 2025Review
- Sperm-borne mRNAs: potential roles in zygote genome activation and epigenetic inheritance.Open biology · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well accepted that sperm carry an RNA cargo with functions in early embryo development. However, most research has focused on the role of small RNAs, such as microRNAs, transfer RNAs and long non-coding RNAs, while protein-coding messenger RNAs (mRNAs) received less attention, even though they represent a substantial amount of the sperm RNA pool. Here, we curated mouse transcriptomic data from mature sperm and selected the most abundant mRNAs (above the 0.7 quantile). The obtained gene list was further filtered using two criteria: (i) mRNAs that are statistically higher in the one-cell embryo compared to the MII oocyte transcriptome, indicative of paternal mRNA contribution after fertilization; and (ii) mRNAs that are found bound to ribosomes in the one-cell embryo, indicative of positive translation in the zygote translatome. Our analysis identified 94 genes that form networks functionally involved in epigenetic chromatin organization, gene expression, RNA processing and translation during zygote genome activation. These findings underscore the significant role of sperm-borne mRNAs in early embryonic development and epigenetic inheritance, highlighting the need for further research to fully understand their functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.