ReviewStructure (London, England : 1993)2025
Structurally diverse C-terminal accessory domains in type I ABC importers reveal distinct regulatory mechanisms.
Review in Structure (London, England : 1993), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Functional characterization of the oligopeptide transporter operon oppABCDF-1 in Escherichia coli Nissle 1917.BMC microbiology · 2026Article
- The molecular mechanism of the cyanobacterial bicarbonate importer CmpABCD activated by the intracellular nitrate.Nature communications · 2026Article
- Analysis of sex difference in strychnine-intoxicated rat based on the combination of metabolic kinetics and metabolomics.Biology of sex differences · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
ATP-binding cassette (ABC) transporters are critical for cellular processes, facilitating the transport of various substrates across membranes by harnessing ATP hydrolysis. These transporters are divided into importers and exporters, with importers playing key roles in nutrient uptake and bacterial virulence. Despite their therapeutic potential as drug targets, the regulatory mechanisms governing ABC importers remain poorly understood. ABC importers often possess additional cytosolic C-terminal accessory domains fused to nucleotide-binding domains (NBDs). These accessory domains, also referred to as C-terminal regulatory domains (CRDs), modulate transport activity by inhibiting NBD dimerization or ATP hydrolysis in response to environmental cues, thus regulating substrate transport. The diversity in CRD folds, architectures, and regulatory mechanisms adds additional complexity to transporter regulation. This review explores the current understanding of C-terminal accessory domains in type I ABC importers, highlighting their contributions to transporter function.
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Registered trials
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