ArticleTranslational oncology2025
Update on the relevance of mechanobiological mechanisms in lung cancer.
Article in Translational oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Metabolic maintenance of breast cancer cells and metastases through E-cadherin/YAP-dependent pyruvate carboxylase expression.bioRxiv : the preprint server for biology · 2026Article
- 3D "Emboli" Culture Models Epithelial Breast Cancer Cell Oxidative Mitochondrial Metabolism with Relevance for Lung Metastasis.Cancer research communications · 2026Article
- The importance of mechanical forces in chronic respiratory diseases.European respiratory review : an official journal of the European Respiratory Society · 2026Review
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4 authors.
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Abstract
Lung tumorigenesis is characterized by mechanical perturbations at the molecular level that affect cancer development, progression and drug efficacy. Tumor expansion, alterations in the matrix stiffness and aberrant mechanical inputs lead to distorted mechanobiology of cancer and stromal cells. This dysregulation is accompanied by oncogenic mechanosignaling facilitating their invasion, migration and immune evasion. A growing volume of data highlight that such molecular events are translated to clinical phenotypes, which encompass a distinct group of oncogenic molecular mechanisms, prognostic and predictive biomarkers as well as putative therapeutic targets in lung cancer.
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