Evidence map›Paper›PMID 40132282›Full record

ArticleSchizophrenia research2025

The STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis.

Laura A Yoviene Sykes, Nina Levine, Sümeyra N Tayfur, Toni Gibbs-Dean, Hadar Hazan, Shannon Imetovski, Josina James, Sneha Karmani, Walter S Mathis, Philip Markovich and 12 more

Abstract read
In one paragraph

Article in Schizophrenia research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Laura A Yoviene SykesProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA. Electronic address: Laura.Yoviene@yale.edu.
Nina LevineProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Sümeyra N TayfurProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Toni Gibbs-DeanProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Hadar HazanProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Shannon ImetovskiProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Josina JamesProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Sneha KarmaniProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Walter S MathisProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Philip MarkovichProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Deepa PurushothamanProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Sarah RileyProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Cenk TekProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Carrie VeilletteProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
John D CahillProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.
Julienne GiardDepartment of Mental Health and Addiction Services (DMHAS), Office of the Commissioner - Community Services Division, Hartford, CT, USA.
Amy MarracinoDepartment of Mental Health and Addiction Services (DMHAS), Office of the Commissioner - Young Adult Services Division, Hartford, CT, USA.
Kyle BarretteDepartment of Mental Health and Addiction Services (DMHAS), Evaluation, Quality Management, and Improvement Division, Hartford, CT, USA.
Stephanie BozakDepartment of Children and Families (DCF), Hartford, CT, USA.
Francis GregoryDepartment of Children and Families (DCF), Hartford, CT, USA.
Glen McDermottRed Rock Branding, New Haven, CT, USA.
Vinod H SrihariProgram for Specialized Treatment Early in Psychosis (STEP), Department of Psychiatry, Yale University School of Medicine & Connecticut Mental Health Center (CMHC), New Haven, CT, USA.

Funding

STEP-ED:Reducing Duration of Untreated Psychosis and its Impact in the U.S.R01MH103831 · NIMH · YALE UNIVERSITY · PI SRIHARI, VINOD H. · 2013 to 2017
$3.9M
Specialized Treatment Early in Psychosis (STEP): A community health center basedRC1MH088971 · NIMH · YALE UNIVERSITY · PI SRIHARI, VINOD H. · 2009 to 2010
$750k
NIMH NIH HHS R01 MH103831NIMH NIH HHS RC1 MH088971
6 · The paper itself

Abstract

The STEP Learning Collaborative (STEP-LC) is Connecticut's statewide learning healthcare system (LHS) for individuals aged 16-35 with recent-onset schizophrenia-spectrum disorders. The goal of the STEP-LC is to ensure that all individuals with schizophrenia have the opportunity to lead fulfilling lives by facilitating rapid access to high-quality treatment during the critical early stages of illness. STEP-LC emphasizes improving local pathways to care, reducing the Duration of Untreated Psychosis, and enhancing population health outcomes. The STEP-LC is a model implementation of a statewide learning health system for recent-onset schizophrenia spectrum disorders. This paper provides a detailed account of the rationale, design and ongoing implementation of the LHS. Several core workstreams organize the activities of the statewide system: workforce development, early detection, informatics, stakeholder engagement, sustainability and care model refinement. The STEP-LC has demonstrated notable initial success in creating a robust system of care for early psychosis across Connecticut. It has implemented comprehensive workstreams to address critical gaps in workforce readiness and information. By leveraging informatics and continuous quality improvement workflows, STEP-LC aims to meet or exceed international benchmarks for access and outcomes of care. Ongoing efforts are focused on further refining care models, sustaining best practices, and strengthening integration with state services through targeted policy advocacy and coordination. This paper serves as a practical guide for those planning to build LHSs in their regions, offering detailed implementation insights to take readers 'behind the scenes' and providing accessible tools for operationalization.

Indexed as

Learning Health SystemPsychotic DisordersSchizophreniaAdolescentAdultConnecticutHumansYoung AdultFirst-episode psychosisLearning health systemSchizophrenia

Identifiers

PMID40132282
PMCPMC11981821

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.