Evidence map›Paper›PMID 40132217›Full record

ArticleThe American journal of tropical medicine and hygiene2025

Chronic Chagas Disease in the Brazilian Amazon: Serological Survey, Clinical Follow-Up, and Associated Risk Factors.

Susan Smith-Doria, Laise Kelma Costa Magalhães, Laylah Kelre Costa Magalhães, Suzane Ribeiro Prestes, Alba Regina Jorge Brandão, Emily de Sousa Moura, Elsa Isela Guevara Moctezuma, Monica Regina Hosanahh da Silva E Silva, Katia do Nascimento Couceiro, Yuliana Padrón-Antonio and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Overview of Chagas disease in Amazonas: an integrated approach.Revista da Sociedade Brasileira de Medicina Tropical · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Susan Smith-DoriaPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Laise Kelma Costa MagalhãesPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Laylah Kelre Costa MagalhãesPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Suzane Ribeiro PrestesPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Alba Regina Jorge BrandãoPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Emily de Sousa MouraPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Elsa Isela Guevara MoctezumaPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Monica Regina Hosanahh da Silva E SilvaPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Katia do Nascimento CouceiroPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Yuliana Padrón-AntonioPrograma de Pós-graduação em biotecnologia e Recursos Naturais, Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas (UEA), Manaus, Brazil.
Victor Irungu MwangiPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Jessica Vanina OrtizPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Leíla Ines Aguiar Raposo Câmara CoelhoUniversidade Federal do Amazonas (UFAM), Manaus, Brazil.
Adriano Gomes-SilvaLaboratório de Pesquisa Clínica em Micobacterioses, Instituto Nacional de Infectologia Evandro Chagas, INI-FIOCRUZ, Rio de Janeiro, Brazil.
Henrique SilveiraPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
João Marcos Bemfica Barbosa FerreiraPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Jorge Augusto de Oliveira GuerraPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.
Maria das Graças Vale Barbosa GuerraPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence and characteristics of chronic Chagas disease (CCD) in the Amazon Region remain underexplored. This study aimed to describe the challenges encountered during a serological survey and follow-up of CCD, while also highlighting potential risk factors in the Amazon Region. The serological survey involved residents of periurban and rural areas of Manaus in the Brazilian Amazon. All participants were invited to complete a clinical, epidemiological, and demographic questionnaire and provide a blood sample for anti-Trypanosoma cruzi (T. cruzi) IgG tests. A total of 1,845 participants were included, of whom 43 were identified as having presumed CCD, based on having at least two positive serological tests. Only 35 underwent complementary tests, and five had cardiac alterations not consistent with CCD. The main risk factors associated with CCD were age ≥20 years, living in periurban areas, reporting the presence of the insect vector inside the household, entering the forest, consumption of bushmeat, and having undergone blood transfusion. In the Amazon, the population is exposed to the sylvatic T. cruzi life cycle and is unaware of the associated risk factors. The divergent serology results raise doubts about the reliability of the commercial serological tests used for CCD screening in the region. Surveillance for CCD is important in the Amazon.

Indexed as

Chagas DiseaseTrypanosoma cruziAdolescentAdultAgedAntibodies, ProtozoanBrazilChronic DiseaseFemaleFollow-Up StudiesHumansImmunoglobulin GMaleMiddle AgedPrevalenceRisk FactorsAntibodies, ProtozoanImmunoglobulin G

Identifiers

PMID40132217
PMCPMC12139563

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.