ArticlePloS one2025
The impact of clot permeability on platelet fluxes toward its surface.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Platelet aggregation is regulated by a series of chemical reactions that control platelet adhesion on a thrombogenic surface. These reactions are influenced by the complex interaction between reaction kinetics and hemodynamics. This study systematically investigates the transport of platelets, considering the interaction between flow-mediated mass transfer mechanisms and reaction kinetics as a function of clot permeability. A two-dimensional finite element model is developed to replicate static blood flow, platelet transport, and adhesion on a semi-elliptical and semi-circular structure representing permeable clots. The platelet-clot interface interactions are extensively investigated using a hindered transport model, focusing on clot permeabilities, reaction rates, and flow conditions. In the case of clots with highly reactive surfaces, an increase in clot permeability can lead up to four-fold increase in total platelet flux compared to non-permeable clots due to differences in transport environments.
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