ReviewPLoS pathogens2025
Dissecting transmission to understand parasite evolution.
Review in PLoS pathogens, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Competition constrains parasite adaptation to thermal heterogeneity.Evolution letters · 2026Article
- Competent Non-Native Alternative Host Reduces Infection Success in a Generalist Parasite.Ecology and evolution · 2026Article
- Testing the redox theory of aging under parasitism.npj aging · 2026Article
- Integrating the Microbiome Into Infection Ecology and Evolution in Wild Animals.Molecular ecology · 2026Review
- Virulence Evolution: Thinking Outside of the Host.Evolutionary applications · 2025Article
- Complex interactions in the life cycle of a simple parasite shape the evolution of virulence.PLoS pathogens · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Parasite transmission is a complex, multi-stage process that significantly impacts host-parasite dynamics. Transmission plays a key role in epidemiology and virulence evolution, where it is expected to trade off with virulence. However, the extent to which classical models on virulence-transmission relationships apply in the real world is unclear. This insight piece proposes a novel framework that breaks transmission into three distinct stages: within-host infectiousness, an intermediate between-host stage (biotic or abiotic), and new host infection. Each stage is influenced by intrinsic and extrinsic factors to the parasite, which together will determine its transmission success. Analyzing the transmission stages separately and how they affect each other might enhance our understanding of which host-, parasite- or environmental-driven factors might shape parasite evolution and inform us about new effectors to act on when designing disease control strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.