Evidence map›Paper›PMID 40132007›Full record

Observational studyPloS one2025

An interoperable web-based platform to support health surveillance against latent tuberculosis infection in health care workers and students: The evolution of CROSSWORD study protocol.

Angela Rizzi, Eleonora Nucera, Walter Mazzucco, Pierpaolo Palumbo, Domenico Staiti, Umberto Moscato, Francesco Maria De Simone, Michela Sali, Luca Boldrini, Nikola Dino Capocchiano and 22 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05756582 (Cross-sectional Study on Prevalence of Latent Tuberculosis Infection in Health-care Workers and Students. A GENERATOR Infrastructure.), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05756582 recruitingnot on this map

Cross-sectional Study on Prevalence of Latent Tuberculosis Infection in Health-care Workers and Students. A GENERATOR Infrastructure.

TypeobservationalSponsorEleonora NuceraRan2021 to 2026Enrolled2,040ConditionsTuberculosis, Tuberculosis, Pulmonary, Tuberculosis Infection, Latent TuberculosisArmsPrevalence of Latent Tuberculosis Infection
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Angela RizziUOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Eleonora NuceraUOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Walter MazzuccoDepartment of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Italy.
Pierpaolo PalumboDepartment of Electrical, Electronic, and Information Engineering "Guglielmo Marconi" - DEI, University of Bologna, Italy.
Domenico StaitiUOSD Sorveglianza sanitaria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Umberto MoscatoSection of Occupational Health, Health Surveillance and Radioprotection Health, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0002-2568-3966
Francesco Maria De SimoneUOSD Sorveglianza sanitaria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Michela SaliDepartment of Laboratory and Infectious Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID 0000-0003-3609-2990
Luca BoldriniUOC Radioterapia Oncologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Nikola Dino CapocchianoGemelli Generator RWD, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Stefano PatarnelloGemelli Generator RWD, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Gabriele RumiUOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID 0000-0001-5990-9129
Raffaella ChiniUOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Valentina CarusiUOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Michele CentroneUOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID 0009-0003-0879-4941
Alessia Di RienzoUOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
David LonghinoUOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Chiara LafaceUOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Sabato MelloneHealth Sciences and Technologies-Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Bologna, Italy.
Carmelo Massimo MaidaDepartment of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Italy.ORCID 0000-0002-6989-9259
Emanuele CannizzaroDepartment of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Italy.
Luigi CirrincioneDepartment of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Italy.
Maria Gabriella VersoDepartment of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Italy.
Annalisa SaracinoDipartimento di Medicina di Precisione e Rigenerativa e Area Jonica (DiMePRe-J), Clinica Universitaria Malattie Infettive, Policlinico di Bari, Italy.
Francesco Di GennaroDipartimento di Medicina di Precisione e Rigenerativa e Area Jonica (DiMePRe-J), Clinica Universitaria Malattie Infettive, Policlinico di Bari, Italy.
Luigi VimercatiInterdisciplinary Department of Medicine (DIM), Unit of Occupational Medicine, University Hospital of Bari, 11 G. Cesare Square, , Bari, Italy.
Luigi De MariaInterdisciplinary Department of Medicine (DIM), Unit of Occupational Medicine, University Hospital of Bari, 11 G. Cesare Square, , Bari, Italy.
Stefania SponselliInterdisciplinary Department of Medicine (DIM), Unit of Occupational Medicine, University Hospital of Bari, 11 G. Cesare Square, , Bari, Italy.
Giancarlo ScoppettuoloUOC Malattie Infettive, Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
Roberta PastorinoSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
Antonio GasbarriniUOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID 0000-0003-4863-6924
Riccardo InchingoloUOC Pneumologia, Dipartimento Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID 0000-0003-2843-9966

Funding

Italian Complementary National Plan PNC-I.1 "Research initiatives for innovative technologies and pathways in the health and welfare sector” D.D. 931 of 06/06/2022, "DARE - DigitAl lifelong pRevEntion" initiative, code PNC0000002
6 · The paper itself

Abstract

backgroundTuberculosis (TB) prevention is a major goal in teaching hospital setting. Because of the possible progression or reactivation of latent disease, the screening of both health-care workers (HCWs) and students is an important issue in the TB control program.

objectiveto deploy a web-based platform interoperating health surveillance systems from different hospitals to define models based on the highlighted risk factors to predict the occurrence of Latent Tuberculosis Infection (LTBI) and to define prevention strategies and interventions.

methodsThis is a cross-sectional ambispective observational study without drug and device. The primary endpoint is the prevalence of LTBI. The secondary endpoint is the identification of possible risk factors of LTBI in a large cohort of HCWs and students.

conclusionsThis study aims to enrich the primary prevention measures against TB, having a high socio-economic-health impact in high-risk populations (HCWs and students) through an interoperable digital approach based on data obtained in three large Italian teaching hospitals. ClinicalTrials.gov: NCT05756582.

Indexed as

Health PersonnelInternetLatent TuberculosisStudentsAdultCross-Sectional StudiesFemaleHumansItalyMalePrevalenceRisk Factors

Identifiers

PMID40132007
PMCPMC11936157

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.