ArticlePloS one2025
Neonatal febrile seizures: Dimethyl itaconate's role in behavioral recovery and glutathione enzyme modulation in adult rats.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Febrile seizures are common in children and can lead to neurological deficits like motor impairments, memory problems, and cognitive decline. Research on dimethyl itaconate aims to mitigate these effects and improve the quality of life for affected people. By exploring its potential as a protective agent against oxidative stress during seizures, this study in adult male rats measures the activity of key enzymes related to oxidative stress and behavioral performance. Pregnant rats were divided into control, sham, DMI, febrile seizure, and DMI + febrile seizure groups. Seizure severity was evaluated through threshold and frequency measurements, while memory, motor function, and balance were assessed using shuttle box, rotarod, open field, and wire hanging tests. After that, the hippocampus tissue was removed from the brain and the levels of MDA, SOD, GSH, TAC, GR, GPx, and catalase were measured through biochemical methods. Results show that dimethyl itaconate raised the seizure threshold and reduced tonic-clonic seizures. The DMI + febrile seizure group also showed improved memory, movement, and balance compared to the febrile seizure group (p < 0.05 in all cases). Overall, dimethyl itaconate decreased oxidative stress and improved neurological outcomes in fever-affected rats.
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Registered trials
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