ArticlePloS one2025
Optical coherence tomography angiography and progressive retinal nerve fiber layer loss in mild to moderate open-angle glaucoma.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Long-term retinal dysfunction following COVID-19 infection: a one-year prospective observational study.BMC ophthalmology · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the association between optical coherence tomography (OCT) angiography measurements and progressive retinal nerve fiber layer (RNFL) loss in eyes with mild to moderate open-angle glaucoma.
methodsIn this prospective study, 111 quadrants of 59 eyes with mild-moderate open-angle glaucoma were longitudinally evaluated for a minimum of 2 years with at least 3 OCT scans performed. OCT angiography was performed at baseline and vessel densities in the peripapillary and parafoveal regions were determined quadrant-wise. Effect of demographic (age, sex, presence of diabetes and hypertension), clinical (mean and fluctuation of intraocular pressure, presence of pseudoexfoliation, presence of disc hemorrhages, central corneal thickness, baseline mean deviation on visual fields) and OCT angiography parameters (peripapillary and parafoveal vessel densities) on rate of RNFL change was determined using linear mixed models.
resultsAverage baseline hemifield mean deviation and quadrant RNFL thickness was -3.5 ± 2.5dB and 97 ± 18µm respectively. The mean follow-up duration was 5.0 ± 1.8 years. The rate of change of quadrant RNFL thickness (RNFL slope) was -1.67 ± 0.2 µm/year. Multivariate mixed models showed that presence of pseudoexfoliation deposits (co-efficient -0.78 ± 0.34, p = 0.025) and optic disc hemorrhages (co-efficient -0.59 ± 0.28, p = 0.040) were associated with a faster rate of RNFL decline. None of the baseline OCT angiography parameters evaluated in this study showed any association with the RNFL slope.
conclusionsPresence of pseudoexfoliation and optic disc hemorrhages are significant risk factors for glaucoma progression in open-angle glaucoma. Baseline superficial vessel density, as measured on OCT angiography, was not associated with the rate of RNFL loss in mild-moderate open-angle glaucoma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.