ArticlePloS one2025
Association of middle cerebral artery aneurysms and variation of the A1 segment.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe disturbance of blood flow caused by variations in the circle of Willis is an important factor in the occurrence and development of aneurysms. Previous studies have confirmed that a fetal-type posterior cerebral artery(PCA) is closely related to posterior communicating artery (PcoA) aneurysms, while anatomical variations of the anterior cerebral artery (ACA) appear to correlate with the prevalence of aneurysms in the anterior communicating artery (ACoA). However, the relationship between variations in the circle of Willis and middle cerebral artery(MCA) aneurysms remains controversial.
methodsThis study retrospectively analyzed the Computed Tomography Angiography (CTA) data of 269 cases of patients with intracranial aneurysms and 269 cases of patients without aneurysms at the Jiangmen Central Hospital from January 2012 to December 2023. The 3D-Slicer software was utilized to measure the artery diameter and investigate the relationship between anatomical variations of the circle of Willis and MCA aneurysm.
resultsIn the aneurysm group, there were 39 cases of A1 dysplasia on the affected side, compared to 20 cases in the control group, with a significantly higher prevalence in the aneurysm group (P = 0.0125). The average diameter of middle cerebral arteries was smaller in the aneurysm group (2.304 ± 0.5613 mm) than in the control group (2.611 ± 0.5500 mm), showing a significant difference (P = 0.001).In aneurysm patients, the MCA diameter on the affected side was smaller in the A1 dysplasia group (2.156 ± 0.5256mm) compared to the A1 normal development group (2.405 ± 0.5718mm, P = 0.0114). Additionally, the average maximum aneurysm diameter was larger in the A1 dysplasia group (6.958 ± 5.163mm) than in the A1 normal development group (5.483 ± 3.336mm, P = 0.03).The presence of ipsilateral A1 dysplasia had a statistically significant effect on the occurrence and rupture of MCA aneurysms.
conclusionsThe variation in the circle of Willis may impact the occurrence and rupture of MCA aneurysms by altering blood flow distribution, constricting the diameter of the parent artery, and shifting the location of blood flow impact.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.