Evidence map›Paper›PMID 40131861›Full record

ArticleAmerican journal of physiology. Renal physiology2025

ACE2 deficiency protects against heme protein-induced acute kidney injury.

Anthony J Croatt, Raman Deep Singh, Joseph P Grande, Allan W Ackerman, Susan B Gurley, Michael A Barry, Luis A Juncos, Karl A Nath

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Anthony J CroattDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Raman Deep SinghDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-1441-2722
Joseph P GrandeDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Allan W AckermanDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Susan B GurleyDepartment of Medicine, Keck School of Medicine of USC, Los Angeles, California, United States.ORCID 0000-0002-2659-6485
Michael A BarryDivision of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Luis A JuncosDepartment of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.ORCID 0000-0002-4630-2747
Karl A NathDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-9869-5506

Funding

Actions of Angiotensin II Along the Nephron to Regulate Blood PressureR01DK098382 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GURLEY, SUSAN BAILEY · 2014 to 2025
$3.8M
Heme-mediated Mitochondrial Injury, Senescence, Acute Kidney Injury and Chronic Kidney DiseaseR01DK133401 · NIDDK · MAYO CLINIC ROCHESTER · PI KARL A. NATH · 2023 to 2026
$2.4M
NIDDK NIH HHS R01 DK098382NIDDK NIH HHS R01 DK133401
6 · The paper itself

Abstract

Angiotensin-converting enzyme 2 (ACE2) exerts countervailing effects on the renin-angiotensin-aldosterone system (RAAS). ACE2 also engages the spike protein of SARS-CoV-2. ACE2 protein has been shown recently to avidly bind heme. We examined the pathobiological relevance of this heme-binding property of ACE2 by using the glycerol-induced model of heme protein-mediated AKI (HP-AKI), which is characterized by increased kidney heme content. We studied the response of ACE2-wildtype (ACE2

Indexed as

Acute Kidney InjuryAngiotensin-Converting Enzyme 2HemeHemeproteinsKidneyAnimalsCOVID-19Disease Models, AnimalGlycerolHumansMaleMiceMice, Inbred C57BLMice, KnockoutAce2 protein, mouseAngiotensin-Converting Enzyme 2GlycerolHemeHemeproteinsACE2acute kidney injuryCOVID-19hemeheme protein

Identifiers

PMID40131861
PMCPMC12188949

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.