Evidence map›Paper›PMID 40131721›Full record

ReviewJournal of endocrinological investigation2025

Adrenal cortex senescence: an ageing-related pathology?

Emma Short, Ramzi Ajjan, Thomas M Barber, Ian Benson, Victoria Higginbotham, Robert Huckstepp, Venkateswarlu Kanamarlapudi, Natasha Mumwiro, Stuart R G Calimport, Barry Bentley

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emma ShortCardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK. eshort@cardiffmet.ac.uk.ORCID http://orcid.org/0000-0001-5050-589X
Ramzi AjjanLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Thomas M BarberWarwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, UK.
Ian BensonUniversity of Glasgow Medical School, Glasgow, UK.
Victoria HigginbothamSwansea University Medical School, Swansea University, Swansea, UK.
Robert HucksteppSchool of Life Sciences, University of Warwick, Coventry, UK.
Venkateswarlu KanamarlapudiSwansea University Medical School, Swansea University, Swansea, UK.
Natasha MumwiroUniversity of Birmingham Medical School, Birmingham, UK.
Stuart R G CalimportCardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK.
Barry BentleyCardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK.

Funding

Impetus Grant, Norn Group Impetus Grant, Norn Group
6 · The paper itself

Abstract

The adrenal glands are a pair of endocrine organs that produce and secrete mineralocorticoids, glucocorticoids, sex hormones, adrenaline, and noradrenaline. They have a vital role in a range of physiological processes including regulating electrolyte balance, blood pressure and metabolism, immunomodulation, sexual development and the stress response. Adrenal cortex senescence describes the ageing-related decline in the normal functioning of the adrenal cortex, characterised by an alteration in the output of adrenal cortical hormones, in particular reduced secretion of dehydroepiandrosterone (DHEA) and sulfated dehydroepiandrosterone (DHEAS). Such endocrine aberrations may be implicated in adverse clinical outcomes including mood disturbances, impairment in cognitive functioning, metabolic dysfunction and osteopenia. This paper shall address whether adrenal cortex senescence should be recognised as an ageing-related pathology, which has recently been defined as one that develops and/or progresses with increasing chronological age, that is associated with, or contributes to, functional decline, and is evidenced by studies in humans.

Indexed as

Adrenal CortexAgingCellular SenescenceAnimalsHumansAdrenal cortex ageingAdrenal cortex senescenceHealthy longevitySenescence

Identifiers

PMID40131721
PMCPMC12313722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.