Evidence map›Paper›PMID 40131690›Full record

ArticleJournal of ultrasound2025

Evolution of focal nodular hyperplasia during long-term ultrasound follow-up: results from a single-center study.

Mattia Paratore, Matteo Garcovich, Annamaria Amodeo, Francesca Fianchi, Francesco Santopaolo, Francesca Romana Ponziani, Maria Assunta Zocco, Antonio Gasbarrini, Laura Riccardi, Maurizio Pompili

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ultrasound, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mattia ParatoreDiagnostic and Interventional Ultrasound Unit, CEMAD Digestive Disease Center, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
Matteo GarcovichDiagnostic and Interventional Ultrasound Unit, CEMAD Digestive Disease Center, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy. matteo.garcovich@policlinicogemelli.it.ORCID http://orcid.org/0000-0002-5805-7953
Annamaria AmodeoInternal Medicine and Liver Transplantation Unit, Catholic University of Sacred Heart, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
Francesca FianchiInternal Medicine and Gastroenterology Unit, CEMAD Digestive Disease Center, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
Francesco SantopaoloInternal Medicine and Gastroenterology Unit, CEMAD Digestive Disease Center, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
Francesca Romana PonzianiInternal Medicine and Gastroenterology Unit, CEMAD Digestive Disease Center, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
Maria Assunta ZoccoInternal Medicine and Gastroenterology Unit, CEMAD Digestive Disease Center, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
Antonio GasbarriniInternal Medicine and Gastroenterology Unit, CEMAD Digestive Disease Center, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
Laura RiccardiDiagnostic and Interventional Ultrasound Unit, CEMAD Digestive Disease Center, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
Maurizio PompiliInternal Medicine and Liver Transplantation Unit, Catholic University of Sacred Heart, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the natural history of focal nodular hyperplasia (FNH) lesions through long-term ultrasound (US) follow-up and assess the relationship between clinical characteristics and size changes.

methodsWe retrospectively enrolled 55 patients diagnosed with FNH who were followed with ultrasound for at least 24 months. A total of 94 FNH nodules were included in the final analysis. A significant change in size was defined as an increase or decrease of 0.5 cm or more, and nodules were classified as increased, decreased or stable. Additionally, we analyzed the association between clinical data and changes in nodule size.

resultsThe mean follow-up duration between the initial US examination at diagnosis and the last available examination was 58.3 ± 33.5 months (range: 24.2-186.6). The majority of nodules remained stable (47.9%) or decreased in size (35.1%), while a small proportion of nodules disappeared (11.7%) and only 7.3% showed an increase in size. No significant association was found between size variation and factors such as oral contraceptive use, pregnancy, BMI or follow-up duration.

conclusionChanges in the size of FNHs during follow-up are relatively common, with most lesions remaining stable or undergoing regression or disappearance over time. These size variations do not appear to be influenced by hormonal factors or other clinical characteristics.

Indexed as

Focal Nodular HyperplasiaAdultAgedDisease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesTime FactorsUltrasonographyYoung AdultBenign liver tumoursFocal nodular hyperplasiaLiver ultrasoundUltrasound follow-up

Identifiers

PMID40131690
PMCPMC12145394

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.