ArticleJournal of assisted reproduction and genetics2025
Association of endometrial preparation protocols and embryonic development stages with ectopic pregnancy in freeze-thaw cycles.
Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the correlation between endometrial preparation protocols, embryonic development stages, and ectopic pregnancy.
methodsA total of 29,700 clinical pregnancies, all of which resulted from freeze-thaw cycles performed between January 2018 and December 2023, were analyzed in this retrospective study.
resultsThe ectopic pregnancy rate was significantly higher in artificial cycles than natural cycles (1.5% vs. 0.8%; P < 0.001); the ectopic pregnancy rate was significantly higher in stage 5-6 than stage 3-4 blastocyst transfer (1.3% vs. 0.7%; P = 0.019). After incorporating all independent confounders into a multivariate general estimating equation model, artificial versus natural cycle (adjusted RR = 1.68, 95% CI = 1.32-2.13; P < 0.001) was shown to be an increased risk factor for ectopic pregnancy, especially in the single embryo transfer subgroup (aRR = 1.75, 95% CI = 1.23-2.48; P = 0.002); additionally, day 3 embryo transfer versus blastocyst transfer (aRR = 1.97, 95% CI = 1.15-3.38; P = 0.014) and stage 5-6 blastocyst versus stage 3-4 blastocyst transfer (aRR = 1.70, 95% CI = 1.05-2.74; P = 0.031) were shown to be increased risk factors for ectopic pregnancy.
conclusionsThis study found that endometrial preparation protocols and embryonic development stages are significantly associated with ectopic pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.