Evidence map›Paper›PMID 40131673›Full record

ArticleBulletin of experimental biology and medicine2025

Activation of the Complement System and Changes in the Content of Modified Lipoproteins in Antiorthostatic Hypokinesia in Humans and Mice.

I B Alchinova, B B Shoibonov, A A Puchkova, M Yu Karganov

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

I B AlchinovaInstitute of General Pathology and Pathophysiology, Moscow, Russia. alchinovairina@yandex.ru.
B B ShoibonovFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.
A A PuchkovaInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
M Yu KarganovInstitute of General Pathology and Pathophysiology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The correlation between the total activity of the complement system (TACS) and the content of modified LDL (mLDL) in blood serum when modeling microgravity in Earth conditions was evaluated. Healthy volunteers were placed in a state of antiorthostatic hypokinesia for 21 days. Microgravity in ICR mice was modeled by tail suspension for 14 days. TACS, activity of the alternative pathway (in humans), and the content of mLDL in serum from volunteers and mice were measured by turbidimetry. On day 7 of antiorthostatic hypokinesia, volunteers had a significant increase in TACS, which persisted until day 21. The content of mLDL in blood serum increased significantly on day 7. In experiments with mice, TACS increased significantly on day 14, and mLDL content decreased significantly. The limitation of mobility, which is an integral part of microgravity modeling, causes an increase in the overall hemolytic activity of the complement system in both humans and laboratory animals, indicating a response to significant physiological stress.

Indexed as

Complement ActivationComplement System ProteinsHypokinesiaLipoproteins, LDLAdultAnimalsComplement Pathway, AlternativeFemaleHindlimb SuspensionHumansMaleMiceMice, Inbred ICRWeightlessnessWeightlessness SimulationComplement System ProteinsLipoproteins, LDLantiorthostatic hypokinesiacomplement systemmicrogravitymodified lipoproteins

Identifiers

PMID40131673

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.