Evidence map›Paper›PMID 40131670›Full record

ArticleBulletin of experimental biology and medicine2025

Involvement of Receptor Apparatus in the Realization of Antinociceptive Activity of Songorine.

Yu V Nesterova, A V Mukhomedzyanov, T N Povetyeva, N I Suslov, P V Kul'pin, O G Afanas'eva, A V Vychuzhanina, O Yu Rybalkina, G N Zyuz'kov, V V Zhdanov and 1 more

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu V NesterovaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences Tomsk, Tomsk, Russia.
A V MukhomedzyanovCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. sasha_m91@mail.ru.
T N PovetyevaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences Tomsk, Tomsk, Russia.
N I SuslovGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences Tomsk, Tomsk, Russia.
P V Kul'pinGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences Tomsk, Tomsk, Russia.
O G Afanas'evaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences Tomsk, Tomsk, Russia.
A V VychuzhaninaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences Tomsk, Tomsk, Russia.
O Yu RybalkinaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences Tomsk, Tomsk, Russia.
G N Zyuz'kovGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences Tomsk, Tomsk, Russia.
V V ZhdanovGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences Tomsk, Tomsk, Russia.
M Yu MinakovaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences Tomsk, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The receptor mechanism of the antinociceptive effect of the diterpene alkaloid songorine was investigated in an experiment on mice. Antagonists of peripheral opioid, κ-opioid, and cannabinoid 1 receptors eliminated the analgesic effect of songorine. These findings suggest that these receptors are involved in the antinociceptive action of songorine.

Indexed as

AlkaloidsAnalgesicsDiterpenesReceptor, Cannabinoid, CB1Receptors, Opioid, kappaAnimalsMaleMiceNaloxoneNaltrexoneNarcotic AntagonistsPainAlkaloidsAnalgesicsDiterpenesNaloxoneNaltrexoneNarcotic AntagonistsReceptor, Cannabinoid, CB1Receptors, Opioid, kappasongorineantinociceptive activitycannabinoid 1 receptorsditerpene alkaloidsperipheral and κ-opioid receptorssongorine

Identifiers

PMID40131670

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.