Evidence map›Paper›PMID 40131655›Full record

ArticleJournal of cardiovascular translational research2025

Induced Human-like Coronary Stenosis in Hypercholesterolemic PCSK9 Minipigs.

Jacob Nicolaisen, Christian Frøsig Bo Poulsen, Martin Mæng Bjørklund, Martin Nors Skov, Maiken Kudahl Larsen, Troels Thim, Jouke Dijkstra, Jacob Fog Bentzon, Evald Høj Christiansen, Niels Ramsing Holm

Abstract read
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In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jacob NicolaisenDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark. jacnic@rm.dk.ORCID 0000-0002-7991-2330
Christian Frøsig Bo PoulsenDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Martin Mæng BjørklundDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Martin Nors SkovInstitute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Maiken Kudahl LarsenDepartment of Forensic Medicine, Aarhus University Hospital, Aarhus, Denmark.
Troels ThimDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Jouke DijkstraDivision of Image Processing, Leiden University Medical Center, Leiden, Netherlands.
Jacob Fog BentzonDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Evald Høj ChristiansenDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Niels Ramsing HolmDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Translational models for obstructive coronary artery disease are lacking. We aimed to develop a porcine model for obstructive coronary stenosis induced by bioresorbable stent (BRS) implantation in hypercholesterolemic proprotein convertase subtilisin/kexin-9 (PCSK9) minipigs. Fifteen hypercholesterolemic PCSK9 minipigs were randomized to percutaneous coronary intervention with Magmaris, Absorb or Desolve BRS. Optical coherence tomography (OCT) scans were performed at baseline and 6-months followed by histology. Matched OCT analysis showed minimal lumen area decreased from 7.62 ± 1.54 mm

Indexed as

Coronary StenosisCoronary VesselsHypercholesterolemiaPercutaneous Coronary InterventionProprotein Convertase 9Absorbable ImplantsAnimalsDisease Models, AnimalFemaleHumansMaleProsthesis DesignSwineSwine, MiniatureTime FactorsTomography, Optical CoherencePCSK9 protein, humanProprotein Convertase 9Animal modelAtherosclerosisBioresorbable stentFibroatheromaObstructive coronary stenosisPercutaneous coronary intervention

Identifiers

PMID40131655
PMCPMC12209001

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.