Evidence map›Paper›PMID 40131519›Full record

ReviewTechniques in coloproctology2025

Bionic concepts for assessment of defecatory function and dysfunction.

D Sun, S Bao, H Yao, Y Hu, Z Huang, P Ran, L Bao, H Gregersen

Abstract readReview
In one paragraph

Review in Techniques in coloproctology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

D Sun *Chongqing Engineering Research Center of Medical Electronics and Information Technology, Chongqing University of Posts and Telecommunications, Chongqing, China.
S Bao *Chongqing Engineering Research Center of Medical Electronics and Information Technology, Chongqing University of Posts and Telecommunications, Chongqing, China.
H YaoChongqing Engineering Research Center of Medical Electronics and Information Technology, Chongqing University of Posts and Telecommunications, Chongqing, China.
Y HuChongqing Engineering Research Center of Medical Electronics and Information Technology, Chongqing University of Posts and Telecommunications, Chongqing, China.
Z HuangSchool of Microelectronics and Communication Engineering, College of Computer Science and Technology, Chongqing University of Posts and Telecommunications, Chongqing, China. zyhuang@cqu.edu.cn.
P RanChongqing Engineering Research Center of Medical Electronics and Information Technology, Chongqing University of Posts and Telecommunications, Chongqing, China.
L BaoCollege of Computer Science and Technology, Chongqing University of Posts and Telecommunications, Chongqing, China.
H GregersenCalifornia Medical Innovations Institute, 11107 Roselle St., San Diego, CA, 92121, USA. hag@giome.org.

Funding

Fecobionics device for mapping colonic and anorectal neuromuscular functionOT2OD025308 · OD · CALIFORNIA MEDICAL INNOVATIONS INSTITUTE · PI GREGERSEN, HANS, KASSAB, GHASSAN S · 2017 to 2020
$3.6M
Pathophysiology, diagnosis and biofeedback therapy in fecal incontinence using fecobionicsR01DK131488 · NIDDK · CALIFORNIA MEDICAL INNOVATIONS INSTITUTE · PI Hans Gregersen, Satish SC Rao · 2022 to 2026
$3.2M
Neurophysiological mechanism in sacral neuromodulation in patients suffering from fecal incontinenceOT2OD028203 · OD · CALIFORNIA MEDICAL INNOVATIONS INSTITUTE · PI GREGERSEN, HANS · 2019 to 2021
$3.1M
Defecation mechanisms and subtyping of constipation patients with FecobionicsR01DK125657 · NIDDK · CALIFORNIA MEDICAL INNOVATIONS INSTITUTE · PI GREGERSEN, HANS · 2021 to 2025
$3.0M
Biomechatronics Device for Diagnosis/Therapy of Anorectal DisordersR44DK129097 · NIDDK · 3DT HOLDINGS, LLC · PI COMBS, WILLIAM, GREGERSEN, HANS · 2021 to 2023
$2.1M
Fecobionics monitoring and prediction of biofeedback therapy outcome in patients with obstructed defecation.R01DK134689 · NIDDK · CALIFORNIA MEDICAL INNOVATIONS INSTITUTE · PI GREGERSEN, HANS, KASSAB, GHASSAN S · 2023 to 2025
$1.1M
National Natural Science Foundation of China #11902057Natural Science Foundation of Chongqing Municipality sl202100000303Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission #CSTB2022NSCQ-MSX0767NIDDK NIH HHS R01 DK125657NIDDK NIH HHS R01 DK131488NIDDK NIH HHS R01 DK134689NIDDK NIH HHS R44 DK129097NIH HHS OT2 OD025308NIH HHS OT2OD025308, OT2ODO28203, R44DK129097, R44DK125657, R44DK131488, and R44DK134689NIH HHS OT2 OD028203
6 · The paper itself

Abstract

Bionic technology is gaining momentum in medical research. In gastroenterology, bionic technologies such as the PillCam and SmartPill assess intestinal mucosa morphology and function during the gastrointestinal passage of the devices. Oral drug delivery devices and intestinal robots are other bionic technologies under development. Recently, Fecobionics, a simulated feces, was developed for assessment of anorectal (defecatory) function. It is an anally insertable device with shape and consistency like feces. The integrated device measures anorectal pressures, orientation, bending (a proxy of the anorectal angle), and the shape of the device when located in rectum and when being evacuated by patients. It integrates most elements of the current technologies on the market (balloon expulsion technology, high-resolution anorectal manometry, defecography, and the functional luminal imaging probe). Multiple measurements in a single study by a bionic device have obvious advantages since novel functional parameters can be computed. Several Fecobionics prototypes have been developed and evaluated in normal human subjects and in patients with fecal incontinence and defecatory disorders such as obstructed defecation. This paper provides an overview of the Fecobionics platform for assessment of defecatory function and dysfunction with a focus on design, signal processing, data analysis, current clinical trials, and future applications in diagnostics, therapy assessment, and therapy.

Indexed as

BionicsConstipationDefecationAnal CanalEquipment DesignFecal IncontinenceHumansManometryRectumBiomechatronicsBionicsDefecatory physiologyFecobionicsFunctional anorectal disorders

Identifiers

PMID40131519
PMCPMC11937068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.