Evidence map›Paper›PMID 40131484›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Assessing safety and feasibility of virtual reality intervention in patients with lung cancer: a pilot study.

Rosalba Hernandez, Harris Nisar, Thenkurussi Kesh Kesavadas, Mackenzie C McGee, Gregory J Gerstner, Angela Martinez, Carter Boyce, Sadia Anjum Ashrafi, Elizabeth L Addington, Alicia K Matthews and 2 more

Abstract readClinical Trial, Phase I
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rosalba HernandezPopulation Health Nursing Science, College of Nursing, University of Illinois Chicago, Chicago, IL, USA. rherna17@uic.edu.
Harris NisarHealth Care Engineering Systems Center, The Grainger College of Engineering, University of Illinois at Urbana-Champaign, Urbana Champaign, IL, USA.
Thenkurussi Kesh KesavadasDivision for Research & Economic Development, University of Albany, Albany, NY, USA.
Mackenzie C McGeeDepartment of Radiology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.
Gregory J GerstnerIllinois Cancercare, P.C., Peoria, IL, USA.
Angela MartinezPopulation Health Nursing Science, College of Nursing, University of Illinois Chicago, Chicago, IL, USA.
Carter BoyceImaging Technology Group, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL, USA.
Sadia Anjum AshrafiPopulation Health Nursing Science, College of Nursing, University of Illinois Chicago, Chicago, IL, USA.
Elizabeth L AddingtonMedical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Alicia K MatthewsPopulation Health Nursing Science, College of Nursing, University of Illinois Chicago, Chicago, IL, USA.
Safa ElkefiBehavior Sciences, School of Nursing, Columbia University, New York, NY, USA.
Judith T MoskowitzMedical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Funding

Virtual Reality: A New Technological Modality to Deliver Psychotherapyto Hemodialysis Patients with Comorbid DepressionR01DK129594 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI HERNANDEZ, ROSALBA, LARA-CINISOMO, SANDRALUZ · 2021 to 2023
$873k
Positive Psychology Intervention for Spanish-speaking Hispanic/Latino Adults at Risk for Cardiovascular DiseaseK01HL130712 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI HERNANDEZ, ROSALBA · 2016 to 2020
$791k
NHLBI NIH HHS K01 HL130712NIDDK NIH HHS R01 DK129594
6 · The paper itself

Abstract

purposeLung cancer, the leading cause of cancer deaths, severely impacts psychological well-being, worsened by the stigma of smoking behavior. This study evaluated the safety, acceptability, and preliminary efficacy of customized virtual reality (VR) software for people with lung cancer, focusing on its potential to enhance mental health in patient care.

methodsPatients with lung cancer undergoing concurrent chemotherapy and radiation therapy were enrolled in our phase 1 single-arm proof-of-concept trial. Participants were immersed in our new Joviality™ VR program during the pre-medication phase of their treatment and engaged in a 25-min 3D session to learn about identifying and benefiting from positive emotions. Participants recorded motion-related symptoms and discomfort using the Simulator Sickness Questionnaire before and after exposure. Pain, anxiety, and fatigue were also captured. Utility measures assessed immersion, interaction with virtual objects, hardware usability, and program navigation ease.

resultsEleven patients enrolled, mean age of 65.8 (± 5.3) years, 72.7% male, 72.7% non-Hispanic White. Only 18.2% had prior VR experience. Participants reported a high sense of presence in the VR environment, scoring 5.26 out of 7, while the system usability score of 78.2 indicated excellent ease of use. Promising safety trends showed no exacerbation of motion sickness, while significant improvements were observed in anxiety (p = 0.04), fatigue (p = 0.03), and pain for preliminary efficacy.

conclusionVR shows promise as an adjunct for enhancing mental health in lung cancer care. Findings suggest feasibility, safety, and early efficacy in reducing psychological distress and symptom burden, warranting investigation in larger-scale trials to confirm benefits.

Indexed as

Lung NeoplasmsVirtual RealityAgedAnxietyFeasibility StudiesFemaleHumansMaleMental HealthMiddle AgedPilot ProjectsProof of Concept StudyLung cancerPatient carePsychological distressSymptom burdenVirtual reality (VR) software

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.