ArticleJournal of neurology2025
Vestibular dysfunction: a hidden risk factor for Alzheimer's disease.
Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Prevalence and direct costs of vestibular disease in France - matched case-control study results from the 2022 and 2023 french health data system.Cost effectiveness and resource allocation : C/E · 2026Article
- Mechanistic research on the vestibular-hippocampal pathway in neurodegenerative diseases: an integrative perspective from molecular to behavioral levels.Frontiers in neuroscience · 2026Review
- Cognitive Decline and Dementia Trajectories by Dizziness Status in Older Adults.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLondon taxi drivers' navigationally challenged hippocampi are known to be enlarged, and reduced Alzheimer's disease (AD)-related mortality has recently been shown in similarly well-versed drivers, implying a neuroprotective effect through hippocampal engagement. Vestibular function has been linked to hippocampal size, suggesting that vestibular input may influence AD risk.
methodsIncluding 16 known modifiable lifestyle factors as covariates, we analyzed UK Biobank (UKB) volunteers aged over 55 years and without dementia at baseline to assess how peripheral vestibular dysfunction (PVD) influences the likelihood of an AD diagnosis.
results4684 AD and 2133 PVD cases were identified based on their ICD diagnoses; even accounting for other risk factors, PVD increased the risk of AD 1.7 times in UKB volunteers. DISCUSSION: Vestibular loss, linked to hippocampal atrophy and default mode network disruption, appears to increase AD risk. Consequently, active vestibular stimulation by balance training or neuromodulation could offer potential for modifying AD progression.
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