ArticleSurgical endoscopy2025
Laparoscopic versus open pancreaticoduodenectomy for pancreatic or periampullary tumors: a multicenter propensity score-matched comparative study.
Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of unplanned conversion to open surgery on resection margins and complications in laparoscopic pancreaticoduodenectomy: a systematic review and meta-analysis with meta-regression.Annals of the Royal College of Surgeons of England · 2026Pooled it
- Observational
- The surgical outcomes of modified Chen's U-suture technique compared with duct-to-mucosa anastomosis in laparoscopic pancreaticoduodenectomy: a multi-center cohort study.Surgical endoscopy · 2026Article
- Comparative Severe Complications After Laparoscopic Pancreatoduodenectomy in PDAC vs Non-PDAC Periampullary Cancer: A Retrospective Cohort Study.Journal of surgical oncology · 2026Article
- Comparative outcomes of laparoscopicWorld journal of gastrointestinal endoscopy · 2026Article
- A comparative analysis of safety and short-term efficacy between open and laparoscopic pancreaticoduodenectomy utilizing different drainage techniques.Frontiers in oncology · 2026Article
- Comparison of endoscopic papillectomy and pancreatoduodenectomy for high-grade intraepithelial neoplasia of the duodenal papilla: a retrospective cohort study.Surgical endoscopy · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundPancreaticoduodenectomy (PD) is a complex surgical procedure for which the use of minimally invasive approaches is still debated. The present study aims to compare the outcomes after laparoscopic pancreaticoduodenectomy (LPD) versus open pancreaticoduodenectomy (OPD) for pancreatic head and peri-ampullary tumors.
methodsThis is a retrospective multicenter study comparing 132 patients who underwent LPD with a historic cohort of OPD performed before LPD program implementation, by two pancreatic and laparoscopic surgeons in tertiary centers. After propensity score-matching (PSM), 85 LPD patients were matched with 85 OPD patients with similar preoperative characteristics and 90-day outcomes were compared.
resultsLPD was associated with significantly longer operative time (355 vs. 269 min; P = 0.001). Estimated blood loss were not different (median = 211 vs 277 mL; P = 0.141) and the conversion to open rate for LPD was 8.33% in the original cohort and 6% after PSM. LPD was not statistically different from OPD for severe complications rates (17.6% vs 24.7%; P = 0.348), clinically relevant POPF (17.6% vs 25.8%; P = 0.265), biliary leakage (17.6% vs 25.8%; P = 0.265), hemorrhage (12.9% vs 14.1%; P = 0.999), delayed gastric emptying rate (10.5% vs 5.8%; P = 0.404) and reoperation rate (12.9% vs 11.7%; P = 0.999). Length of stay in the LPD group was shorter than in the OPD group (15.13 vs. 19.44 days; P = 0.01). Mortality rates (3.5% vs. 0%; P = 0.245) did not differ between LPD and OPD groups. Regarding final histology, we found a higher number of lymph nodes in the LPD group (15.48 vs 13.46; P = 0.017) without difference on R0 rates.
conclusionLPD is a safe procedure when performed by pancreatic and laparoscopic surgeons and could lead to a shorter hospital stay and improve lymphadenectomy with similar postoperative outcomes to OPD.
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