Evidence map›Paper›PMID 40131447›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

Incomplete concordance between laboratory and pathologic findings on post-induction kidney biopsy in pediatric patients with proliferative lupus nephritis.

Robin Raschke, Clarkson Crane, Robert Sheets, Noureddin Nourbakhsh, Nadine Benador, Elizabeth Ingulli, Katayoon Shayan, Peter Yorgin, Caitlin Carter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Robin RaschkeSan Diego Department of Pediatrics, Rady Children's Hospital, San Diego and University of California, La Jolla, CA, USA. rraschke@health.ucsd.edu.ORCID 0000-0002-3910-1103
Clarkson CraneSan Diego Department of Pediatrics, Rady Children's Hospital, San Diego and University of California, La Jolla, CA, USA.
Robert SheetsSan Diego Department of Pediatrics, Rady Children's Hospital, San Diego and University of California, La Jolla, CA, USA.
Noureddin NourbakhshSan Diego Department of Pediatrics, Rady Children's Hospital, San Diego and University of California, La Jolla, CA, USA.
Nadine BenadorSan Diego Department of Pediatrics, Rady Children's Hospital, San Diego and University of California, La Jolla, CA, USA.
Elizabeth IngulliSan Diego Department of Pediatrics, Rady Children's Hospital, San Diego and University of California, La Jolla, CA, USA.
Katayoon ShayanSan Diego Department of Pediatrics, Rady Children's Hospital, San Diego and University of California, La Jolla, CA, USA.
Peter YorginSan Diego Department of Pediatrics, Rady Children's Hospital, San Diego and University of California, La Jolla, CA, USA.
Caitlin CarterSan Diego Department of Pediatrics, Rady Children's Hospital, San Diego and University of California, La Jolla, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProliferative lupus nephritis (LN) is associated with increased risk of progression to kidney failure. After initial kidney biopsy, the utility and timing of subsequent biopsies is unknown. There is known discordance between the laboratory parameters used to diagnose LN and the histopathologic classification. We explore the utility of a subsequent kidney biopsy in guiding treatment of LN to determine the factors that warrant follow-up kidney biopsy.

methodsWe conducted a single center retrospective cohort study of 30 SLE patients who underwent serial kidney biopsy for LN. Subjects were stratified based on their Childhood Arthritis and Rheumatology Research Alliance (CARRA) renal response into complete renal response (CRR) and incomplete renal response (IRR) groups at the time of second biopsy.

resultsAmong 30 patients with LN, 11/18 in CRR group and 11/12 in IRR group had persistent proliferative nephritis at 1 ± 0.3 years after initial biopsy. Only SLEDAI score was associated with an increased risk of persistent proliferative nephritis (p = 0.03). Initial CARRA response category was associated with outcome at last follow-up (mean 4.5 years), with 11/18 CRR and 3/12 IRR achieving CRR at last follow-up at mean 4.5 years (p < 0.001). Kidney biopsy directly impacted clinical decision in 7/18 CRR patients in the CRR group who had therapy escalated or reduction withheld due to biopsy findings.

conclusionsAvailable laboratory markers in LN are insufficient to identify children with ongoing proliferative nephritis. Follow-up kidney biopsy may be warranted for children with CRR at 1 year after initial biopsy.

Indexed as

KidneyLupus NephritisAdolescentBiopsyChildChild, PreschoolDisease ProgressionFemaleFollow-Up StudiesHumansMaleRetrospective StudiesBiopsyChildrenKidney failureOutcomesProliferative lupus nephritis

Identifiers

PMID40131447
PMCPMC12296845

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.