Evidence map›Paper›PMID 40131437›Full record

ArticleAnalytical and bioanalytical chemistry2025

Engineering DNA circuit powered by entropy integrated into robust and elegant photoelectrochemical and photothermal dual-mode biosensing.

Jing Li, Bingtao Hu, Yanxin Zhang, Qin Xu, Hongbo Li

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jing LiSchool of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, 224051, P. R. China.
Bingtao HuSchool of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, 224051, P. R. China.
Yanxin ZhangSchool of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, 224051, P. R. China. zyx942518@163.com.
Qin XuInstitute of Innovation Materials and Energy, Yangzhou University, Yangzhou, 225002, P. R. China.
Hongbo LiSchool of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, 224051, P. R. China. hbli@ycit.edu.cn.

Funding

National Natural Science Foundation of China 22176165National Natural Science Foundation of China 22276161National Natural Science Foundation of China 22474123Natural Science Foundation of Jiangsu Province BK20211362
6 · The paper itself

Abstract

Dual-signal mode sensors that can self-validate detection results have attracted considerable interest; however, creating those with superior overall performance still presents significant challenges. Herein, we develop a unique photoelectrochemical (PEC) and photothermal (PT) dual-mode biosensor targeting microRNA-221 (miRNA-221), built on an innovative entropy-driven DNA circuit (EDC). The zinc oxide nanorods (ZnO NRs) serve as PEC beacons, while copper sulfide nanoparticles (CuS NPs) function as photocurrent inhibitors and PT beacons, both biofunctionalized with DNAs before being assembled through partial base pairing. When target miRNA-221 is present, the EDC activates and releases output DNAs that open partially hybridized strands anchored to ZnO NRs via competitive assembly. This process liberates CuS-DNA1 and restores the suppressed photocurrent. The results demonstrate linear relationships between photocurrent/temperature increment and the logarithm of target concentration across ranges of 1.0 fmol L

Indexed as

Biosensing TechniquesDNAElectrochemical TechniquesMicroRNAsCopperEntropyLimit of DetectionNanotubesPhotochemical ProcessesSulfidesZinc OxideCopperDNAMicroRNAsSulfidesZinc OxideDual-mode biosensingElectrodepositionEntropy-driven DNA circuitPhotoelectric convertingPhotothermal conversion

Identifiers

PMID40131437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.