Rapid screening of α-amylase inhibitors from Aloe vera based on polydopamine/L-cysteine bifunctionalized magnetic mesoporous silica immobilized α-amylase.

Lei Wang, Yue Li, Sikai Wang, Lin Lv, Hongmei Liu, Guoqi Zhang, Yan Zhao

Abstract read

In one paragraph

Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Lei WangSchool of Science, Xihua University, Chengdu, 610039, China.

Yue LiSchool of Science, Xihua University, Chengdu, 610039, China.

Sikai WangSchool of Science, Xihua University, Chengdu, 610039, China.

Lin LvSchool of Science, Xihua University, Chengdu, 610039, China.

Hongmei LiuSchool of Science, Xihua University, Chengdu, 610039, China.

Guoqi ZhangSchool of Science, Xihua University, Chengdu, 610039, China.

Yan ZhaoSchool of Science, Xihua University, Chengdu, 610039, China. zhao518yan@163.com.

Funding

the Science and Technology Programs of Sichuan Province of China 2024NSFSC2077

6 · The paper itself

Abstract

Diabetes mellitus is a metabolic disorder that impacts millions of individuals globally. In the treatment of this condition, it is imperative to explore natural resources for therapeutic agents that exhibit fewer adverse effects and enhanced efficacy. Currently, the methods employed for isolating anti-diabetic lead compounds from natural sources are often intricate and time-consuming. Therefore, there is an urgent need to develop efficient and rapid screening techniques. In this study, α-amylase was immobilized using a novel polydopamine/L-cysteine bifunctionalized magnetic mesoporous silica composite material (Fe

Indexed as

Aloealpha-AmylasesCysteineEnzyme InhibitorsEnzymes, ImmobilizedIndolesPolymersSilicon DioxideChromatography, High Pressure LiquidMolecular Docking SimulationPorosityalpha-AmylasesCysteineEnzyme InhibitorsEnzymes, ImmobilizedIndolespolydopaminePolymersSilicon DioxideAloe veraInhibitor screeningMagnetic mesoporous silicaMolecular dockingα-Amylase

Identifiers

PMID40131436

DOI10.3390/agronomy9120831

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.