Evidence map›Paper›PMID 40131428›Full record

ArticleUrolithiasis2025

The role of osteopontin in modulating macrophage phagocytosis of calcium oxalate crystals.

Tatsuya Hattori, Kazumi Taguchi, Ryosuke Chaya, Shuzo Hamamoto, Atsushi Okada, Takahiro Yasui

Abstract read
PubMed Publisher
In one paragraph

Article in Urolithiasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tatsuya Hattori *Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Kazumi Taguchi *Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. ktaguchi@med.nagoya-cu.ac.jp.ORCID http://orcid.org/0000-0002-3092-5114
Ryosuke ChayaDepartment of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Shuzo HamamotoDepartment of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Atsushi OkadaDepartment of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Takahiro YasuiDepartment of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Funding

Japan Society for the Promotion of Science 23K27730, 23K08763, 23K08744, and 22H00486
6 · The paper itself

Abstract

In inflammation, osteopontin (OPN) acts as both a stone matrix component for calcium oxalate (CaOx) crystal formation and an inflammatory mediator. While previous studies have demonstrated the individual roles of OPN and macrophages (Mφ) in renal CaOx stone formation during inflammation, their interaction remains poorly understood. This study aimed to elucidate the role of OPN in modulating Mφ function during crystal formation, using an ex vivo model. Bone marrow-derived macrophages (BMDM) were isolated from eight-week-old male C57BL/6J wild-type and OPN knockout mice. BMDMs from OPN-positive (BMDM

Indexed as

Calcium OxalateKidney CalculiMacrophagesOsteopontinPhagocytosisAnimalsCells, CulturedMaleMiceMice, Inbred C57BLMice, KnockoutCalcium OxalateOsteopontinSpp1 protein, mouseCalcium oxalateM2-likeMacrophageOsteopontinPhagocytosis

Identifiers

PMID40131428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.