Evidence map›Paper›PMID 40131268›Full record

ArticleACS infectious diseases2025

Genetic and Cheminformatic Characterization of

Ifeanyichukwu E Eke, John T Williams, Robert B Abramovitch

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ifeanyichukwu E EkeDepartment of Microbiology, Genetics & Immunology, Michigan State University, East Lansing, Michigan 48824, United States.
John T WilliamsDepartment of Microbiology, Genetics & Immunology, Michigan State University, East Lansing, Michigan 48824, United States.
Robert B AbramovitchDepartment of Microbiology, Genetics & Immunology, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0002-4119-4169

Funding

Treatments for Nipah Virus InfectionU54AI057159 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WHELAN, SEAN PJ · 2003 to 2013
$113.7M
Integrative Pharmacological Sciences Training Program (IPSTP)T32GM142521 · NIGMS · MICHIGAN STATE UNIVERSITY · PI ANNE M. DORRANCE, Gina Marie Leinninger · 2021 to 2026
$2.4M
Screening for inhibitors of M. tuberculosis persistence-related lipid metabolismR21AI105867 · NIAID · MICHIGAN STATE UNIVERSITY · PI ABRAMOVITCH, ROBERT B · 2013 to 2014
$392k
Characterizing new M. tuberculosis inhibitors discovered in the Molecular Libraries Small Molecule RepositoryR03AI153454 · NIAID · MICHIGAN STATE UNIVERSITY · PI ABRAMOVITCH, ROBERT B · 2020 to 2021
$149k
NIAID NIH HHS R03 AI153454NIAID NIH HHS R21 AI105867NIAID NIH HHS U54 AI057159NIGMS NIH HHS T32 GM142521
6 · The paper itself

Abstract

High-throughput screening (HTS) of small molecules is a starting point for many drug development pipelines, including tuberculosis. These screens often result in multiple hits whose mechanisms of action remain unknown. From our initial HTS of the Molecular Libraries Small Molecule Repository (MLSMR), we cherry-picked 935 compounds that inhibited the growth of

Indexed as

Antitubercular AgentsMycobacterium tuberculosisSmall Molecule LibrariesBacterial ProteinsCatalaseCheminformaticsDrug DiscoveryHigh-Throughput Screening AssaysHumansIsoniazidMembrane Transport ProteinsMicrobial Sensitivity TestsMutationAntitubercular AgentsBacterial ProteinsCatalaseIsoniazidkatG protein, Mycobacterium tuberculosisMembrane Transport ProteinsMmpL3 protein, Mycobacterium tuberculosisSmall Molecule Librariesantibioticsmechanism of actionMycobacterium tuberculosisphenotypic screening

Identifiers

PMID40131268
PMCPMC11997997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.