Evidence map›Paper›PMID 40131119›Full record

ArticleJACC. Basic to translational science2025

Endothelial JCAD Worsens Acute Ischemic Stroke Outcomes by Enhancing Inflammation in Response to Ischemia/Reperfusion.

Stefano Ministrini, Yustina M Puspitasari, Georgia Beer, Lena Schwarz, Rebecca Niederberger, Simon Kraler, Florian A Wenzl, Mira Katan, Marco Bacigaluppi, Aurora Semerano and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Stefano MinistriniCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Schlieren, Switzerland.
Yustina M PuspitasariCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Schlieren, Switzerland.
Georgia BeerCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Schlieren, Switzerland.
Lena SchwarzCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Schlieren, Switzerland.
Rebecca NiederbergerCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Schlieren, Switzerland.
Simon KralerCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital Baden, Baden, Switzerland.
Florian A WenzlCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Schlieren, Switzerland; National Disease Registration and Analysis Service, National Health Service, London, United Kingdom; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; Department of Clinical Sciences, Karolinska Institutet, Stockholm, Sweden.
Mira KatanDepartment of Neurology, University and University Hospital of Basel, Basel, Switzerland.
Marco BacigaluppiCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Schlieren, Switzerland; Department of Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Aurora SemeranoDepartment of Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Alexander AkhmedovCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Schlieren, Switzerland.
Susan BengsCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Schlieren, Switzerland.
Fabrizio MontecuccoFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino Genoa-Italian Cardiovascular Network Genoa, Genoa, Italy.
Thomas F LüscherCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Schlieren, Switzerland; Royal Brompton and Harefield Hospitals and Imperial College, London, United Kingdom.
Giovanni G CamiciCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Schlieren, Switzerland; Department of Research and Education, University Hospital Zurich, Zurich, Switzerland.
Luca LiberaleFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino Genoa-Italian Cardiovascular Network Genoa, Genoa, Italy. Electronic address: luca.liberale@unige.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of junctional protein associated with coronary artery disease (JCAD) in acute ischemic stroke (AIS) has not been investigated yet. To investigate its potential as a therapeutic target, transient middle cerebral artery occlusion was induced in JCAD knockout mice, with improvement of stroke outcome and reduced blood-brain barrier permeability and expression of vascular cell adhesion molecule (VCAM)-1. JCAD plays a deleterious role in ischemia/reperfusion cerebral damage and associates with higher 90-day mortality in patients with AIS. JCAD may thus represent a novel prognostic biomarker for patients with AIS, as well as a therapeutic target.

Indexed as

acute ischemic strokeblood-brain barrierendothelial cellshypoxia/reoxygenationinflammation

Identifiers

PMID40131119
PMCPMC11897444

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.