Evidence map›Paper›PMID 40131046›Full record

ArticlePhysical review letters2025

Mid-Infrared Energy Deposition Spectroscopy.

Jiaze Yin, Christian Pfluegl, Chu C Teng, Rylie Bolarinho, Guo Chen, Xinrui Gong, Dashan Dong, Daryoosh Vakhshoori, Ji-Xin Cheng

Abstract read
In one paragraph

Article in Physical review letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiaze YinBoston University, Department of Electrical and Computer Engineering, Boston, Massachusetts 02215, USA.
Christian PflueglPendar Technologies, Cambridge, Massachusetts 02138, USA.
Chu C TengPendar Technologies, Cambridge, Massachusetts 02138, USA.
Rylie BolarinhoBoston University, Photonics Center, Boston, Massachusetts 02215, USA.
Guo ChenBoston University, Department of Electrical and Computer Engineering, Boston, Massachusetts 02215, USA.
Xinrui GongBoston University, Photonics Center, Boston, Massachusetts 02215, USA.
Dashan DongBoston University, Department of Electrical and Computer Engineering, Boston, Massachusetts 02215, USA.
Daryoosh VakhshooriPendar Technologies, Cambridge, Massachusetts 02138, USA.
Ji-Xin ChengBoston University, Department of Electrical and Computer Engineering, Boston, Massachusetts 02215, USA.

Funding

Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living SystemsR35GM136223 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2020 to 2025
$5.7M
High-content High-speed Chemical Imaging of Metabolic Reprogramming by Integration of Advanced Instrumentation and Data ScienceR01EB032391 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2022 to 2025
$2.0M
Super-sensitive vibrational imaging by synergic development of instruments and probesR01EB035429 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Daniela Buccella, Ji-Xin Cheng · 2024 to 2026
$1.8M
Bio-orthogonal Mid-Infrared Photothermal Imaging of Cancer MetabolismR33CA287046 · NCI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Ji-Xin Cheng · 2024 to 2026
$1.2M
Mapping Cancer Metabolism by Mid-infrared Photothermal MicroscopyR33CA261726 · NCI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2021 to 2023
$1.2M
Multimodal multiphoton imaging of nervous system ex vivo and in vivoR01EB007243 · NIBIB · PURDUE UNIVERSITY · PI CHENG, JI-XIN · 2007 to 2009
$950k
NCI NIH HHS R33 CA261726NCI NIH HHS R33 CA287046NIBIB NIH HHS R01 EB007243NIBIB NIH HHS R01 EB032391NIBIB NIH HHS R01 EB035429NIGMS NIH HHS R35 GM136223
6 · The paper itself

Abstract

It is generally assumed that the spectral acquisition speed in photothermal spectroscopy is fundamentally limited by the thermal diffusion process. Here, we demonstrate midinfrared energy deposition (MIRED) spectroscopy that offers both microsecond-scale temporal resolution and submicron spatial resolution. In this approach, the photothermal process is optically probed while the infrared pulses from a quantum cascade laser array are rapidly tuned. Based on Newton's law of heating and cooling, the energy deposition is the first derivative of local temperature rise over time and gives the instantaneous absorption. By employing time-resolved measurement of transient energy deposition, the upper limit for spectrum encoding shifts to the vibrational relaxation level, which occurs on the picosecond scale. This method significantly increases the detection bandwidth while retaining the sensitivity and resolution benefits of photothermal detection.

Identifiers

PMID40131046
PMCPMC12234123

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.