ArticleJournal of clinical microbiology2025
Evaluation of the cobas MTB and MTB-RIF/INH assay in clinical samples for the detection of
Article in Journal of clinical microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Current Landscape of Molecular Diagnostic Tests and Emerging Tools for Tuberculosis and Drug Resistance.Diagnostics (Basel, Switzerland) · 2026Review
- Clinical utility of targeted next-generation sequencing for rapid detection, species differentiation, drug resistance profiling, and prognostic evaluation inFrontiers in cellular and infection microbiology · 2026Article
- At the crossroads of infection and malignancy: the challenge of tuberculosis in migrating populations - Case Report and Epidemiologic Analysis.BMC infectious diseases · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the performance of the automated cobas MTB-Real-Time PCR assay for the rapid direct detection of IMPORTANCE: Our manuscript addresses the WHO recommendation for the use of "moderate-complexity automated NAATs for detection of TB and resistance to rifampicin and isoniazid" as a part of the WHO End TB Strategy. Rapid detection of tuberculosis (TB) patients is essential to preventing TB transmission and finally reducing TB burden. In this study, we present data on the sensitivity and specificity of the novel cobas MTB assay for TB detection in a low-incidence country, demonstrating highly promising results. Additionally, by analyzing TB strains with various mutations conferring resistance to INH and/or RMP, we assess the opportunities and limitations of the cobas MTB-RIF/INH assay in reliably detecting drug resistance in sputum specimens, thereby facilitating the early onset of appropriate treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.