Evidence map›Paper›PMID 40130878›Full record

ArticleJournal of virology2025

Human long noncoding RNA

Kristen John, Ian Huntress, Ethan Smith, Hsuan Chou, Tammy S Tollison, Sergio Covarrubias, Elisa Crisci, Susan Carpenter, Xinxia Peng

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Journal of virology · 2026
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Kristen John *Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.ORCID 0000-0003-1621-7370
Ian Huntress *Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.
Ethan SmithDepartment of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.ORCID 0000-0001-8897-2143
Hsuan ChouDepartment of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.
Tammy S TollisonDepartment of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.ORCID 0000-0002-7193-8456
Sergio CovarrubiasDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, USA.ORCID 0000-0002-7197-9952
Elisa CrisciDepartment of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.ORCID 0000-0002-4235-8508
Susan CarpenterDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, USA.ORCID 0000-0002-5600-5404
Xinxia PengDepartment of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.ORCID 0000-0002-0117-3582

Funding

High throughput functional characterization of lncRNAs in macrophage biologyR35GM137801 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CARPENTER, SUSAN · 2020 to 2024
$2.2M
Define long non-coding RNA regulatory mechanisms of host response to influenza infectionR21AI147187 · NIAID · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI PENG, XINXIA · 2019 to 2020
$405k
NIAID NIH HHS R21 AI147187NIGMS NIH HHS R35 GM137801NIH HHS R21 AI147187NIH HHS R35 GM137801
6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) are a newer class of noncoding transcripts identified as key regulators of biological processes. Here, we aimed to identify novel lncRNA targets that play critical roles in major human respiratory viral infections by systematically mining large-scale transcriptomic data sets. Using bulk RNA-sequencing (RNA-seq) analysis, we identified a previously uncharacterized lncRNA, named virus-inducible lncRNA modulator of interferon response (

Indexed as

COVID-19Influenza, HumanRNA, Long NoncodingA549 CellsCell LineEpithelial CellsHost-Pathogen InteractionsHumansInfluenza A virusInterferon-betaInterferonsRespiratory Syncytial Virus InfectionsSARS-CoV-2Interferon-betaInterferonsRNA, Long NoncodinginfluenzainterferonISGlncRNARNA-seqRSVSARS-CoV-2

Identifiers

PMID40130878
PMCPMC11998520

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.