ArticlePM & R : the journal of injury, function, and rehabilitation2025
A single-arm feasibility study protocol for a multiphasic multimodal exercise prehabilitation intervention in individuals receiving allogeneic stem cell transplant.
Article in PM & R : the journal of injury, function, and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A single-arm feasibility study protocol for a multiphasic multimodal exercise prehabilitation intervention in individuals receiving allogeneic stem cell transplant.PM & R : the journal of injury, function, and rehabilitation · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundAllogeneic hematopoietic stem cell transplantation (allo-HSCT) can be a life-saving treatment for individuals diagnosed with acute leukemia. However, allo-HSCT can lead to adverse effects, such as reduced physical function. Exercise has demonstrated benefits in post-allo-HSCT recovery, but feasibility issues persist in tailored prehabilitation interventions.
objectiveTo present a multiphasic exercise prehabilitation protocol.The study aims to assess feasibility, safety, and impact while establishing screening and referral pathways to community-based exercise oncology resources.
designSingle arm feasibility study.
participantsIndividuals diagnosed with acute leukemia and eligible for allo-HSCT will be recruited for the study.
interventionMultimodal exercise and health behavior change support that will span across the allo-HSCT timeline (ie, pre-, during, and post-transplant phases). Clinical exercise physiologists trained in exercise oncology and health behavior change will deliver the intervention.
main outcome measuresAssessment of physical function, self-reported and objective physical activity, quality of life, fatigue, anxiety, depression, and symptom burden across four timepoints (baseline, pre-transplant, post-transplant inpatient recovery, and post-transplant outpatient recovery).
conclusionsThis study is designed to address current limitations in prehabilitation literature specific to individuals with acute leukemia receiving allo-HSCT. In turn, this study may offer an approach to maintain or improve physical function and quality of life throughout the transplant continuum.
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