Evidence map›Paper›PMID 40130686›Full record

ArticleMovement disorders clinical practice2025

Rest-Activity Disturbances Correlate with Core Features in Dementia with Lewy Bodies.

Jack Anderson, Nicholas K H Chiu, Jonathon E Pye, Maria Comas-Soberats, Aaron Lam, Ronald R Grunstein, Simon J G Lewis, Elie Matar

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In one paragraph

Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jack AndersonFaculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0009-0006-4967-7372
Nicholas K H ChiuFaculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-9012-8010
Jonathon E PyeHealthy Brain Aging Program, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Maria Comas-SoberatsCentre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
Aaron LamCentre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
Ronald R GrunsteinCentre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
Simon J G LewisFaculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-4093-7071
Elie MatarFaculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-4994-0488

Funding

National Health and Medical Research Council 1195830National Health and Medical Research Council 2008565U.S. Department of Defense PD220061
6 · The paper itself

Abstract

backgroundSleep-wake disturbances are a clinically important and poorly studied feature of dementia with Lewy bodies (DLB) due to the challenges of in-laboratory polysomnography in this population.

objectivesTo compare rest-activity rhythms in DLB, Parkinson's disease (PD), and age-matched controls using home-based wrist actigraphy and examine their relationship with core clinical DLB features.

methodsEleven DLB patients, 12 PD patients, and 11 age-matched controls underwent clinical assessment. Actigraphy data were obtained over 14 days and analyzed using nonparametric methods.

resultsDLB patients demonstrated higher rest-activity rhythm fragmentation (P = 0.002) than controls and lower circadian amplitude (P = 0.011) than both PD and controls. Instability of rest-activity rhythm was positively correlated with hallucinations (P = 0.009) and cognitive fluctuations (P = 0.016) in DLB, and reduced daytime activity correlated with severity of motor parkinsonism (P = 0.013). No such correlations were observed in PD.

conclusionsActigraphy detects distinct rest-activity rhythm disruptions in DLB, differentiating it from PD and controls. These measures are associated with the severity of core clinical features in DLB.

Indexed as

Lewy Body DiseaseRestSleep Wake DisordersActigraphyAgedAged, 80 and overFemaleHumansMaleMiddle AgedParkinson Diseaseactigraphydementia with Lewy bodiesDLBnonparametricsleep

Identifiers

PMID40130686
PMCPMC12371458

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.