Evidence map›Paper›PMID 40130680›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Molecular Stiffening by Macrocycle Clustering.

Hang Yin, Qian Cheng, Roselyne Rosas, Stéphane Viel, Valerie Monnier, Laurence Charles, Didier Siri, Didier Gigmes, Mehdi Yemloul, Ruibing Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Molecular Stiffening by Macrocycle Clustering.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hang YinState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau Taipa, Macau, China.
Qian ChengState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau Taipa, Macau, China.
Roselyne RosasAix Marseille Univ, CNRS, Centrale Marseille, FSCM, Spectropole, Marseille, France.
Stéphane VielAix Marseille Univ, CNRS, ICR, AMUtech, Marseille, France.
Valerie MonnierAix Marseille Univ, CNRS, Centrale Marseille, FSCM, Spectropole, Marseille, France.
Laurence CharlesAix Marseille Univ, CNRS, ICR, AMUtech, Marseille, France.
Didier SiriAix Marseille Univ, CNRS, ICR, AMUtech, Marseille, France.
Didier GigmesAix Marseille Univ, CNRS, ICR, AMUtech, Marseille, France.
Mehdi YemloulAix Marseille Univ, CNRS, ISM2, AMUtech, Marseille, France.
Ruibing WangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau Taipa, Macau, China.
Anthony KermagoretAix Marseille Univ, CNRS, CINaM, AMUtech, Marseille, France.
David BardelangAix Marseille Univ, CNRS, ICR, AMUtech, Marseille, France.

Funding

Agence Nationale de la RechercheCentre National de la Recherche ScientifiqueFondation Aix-Marseille UniversiteUniversity of Macau
6 · The paper itself

Abstract

Allosteric stiffening of a portion of a protein surface is a strategy used in nature to regulate protein oligomerization and provide crucial functions for cells. However, a similar strategy to selectively control part of a compound dynamics remains elusive. Here we show that cucurbit[n]uril (CB[n]) macrocycles can bind almost all portions of a tetratopic guest molecule, stiffening the different parts of the guest to different extents. "Host-guest" interactions were found to be instrumental in selectively "freezing" guest molecular motions. The combination of

Indexed as

Bridged-Ring CompoundsImidazolesMacrocyclic CompoundsCalorimetryCucurbit(n)urilsHeterocyclic Compounds, 2-RingImidazolidinesModels, MolecularMolecular StructureBridged-Ring Compoundscucurbit(8)urilCucurbit(n)urilsHeterocyclic Compounds, 2-RingImidazolesImidazolidinesMacrocyclic CompoundsCucurbiturilMacrocyclesRigidificationSupramolecularTetratopic

Identifiers

PMID40130680
PMCPMC12105694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.