Article in Chemical research in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
5 authors.
Xueshu LiDepartment of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa 52242, United States.ORCID 0000-0002-0881-5381
Joe J LimDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, United States.ORCID 0000-0002-6726-2684
Cayen RongDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, United States.ORCID 0009-0009-2179-080X
Hans-Joachim LehmlerDepartment of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa 52242, United States.ORCID 0000-0001-9163-927X
Julia Yue CuiDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, United States.
Funding
Training CoreP42ES013661 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 2006 to 2026
$60.3M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Environmetal Pathology/Toxicology Training ProgramT32ES007032 · NIEHS · UNIVERSITY OF WASHINGTON · PI FAUSTMAN, ELAINE M, ROSENFELD, MICHAEL E · 1985 to 2023
$10.7M
Molecular and Cellular Basis of PCB Developmental Neurotoxicity: ViCTER supplementR01ES014901 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HANS-JOACHIM LEHMLER, Pamela J Lein · 2009 to 2026
$9.3M
Developmental PBDE exposure, gut microbiome, and diabetesR01ES030197 · NIEHS · UNIVERSITY OF WASHINGTON · PI Julia Yue Cui, Haiwei Gu · 2019 to 2026
$5.0M
PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?R01ES031098 · NIEHS · UNIVERSITY OF IOWA · PI CUI, JULIA YUE, LEHMLER, HANS-JOACHIM · 2020 to 2024
$3.1M
Environmental factors in pathobiology of dementia: the role of PCB exposure, microbiome, and tissue barrier dysfunctionR01ES034691 · NIEHS · UNIVERSITY OF IOWA · PI LEHMLER, HANS-JOACHIM · 2023 to 2025
$2.2M
Molecular and Cellular Basis of PCB Developmental NeurotoxicityR56ES014901 · NIEHS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEIN, PAMELA J · 2007 to 2007
$150k
Late onset of metabolic liver disease from early life flame retardant exposure and adulthood western dietF31DK139707 · NIDDK · UNIVERSITY OF WASHINGTON · PI LIM, JONGPYO JOE · 2024 to 2025
The role of the gut microbiome in metabolizing polychlorinated biphenyls (PCBs), toxic environmental contaminants, and their metabolites remains unclear. This study used mouse and human microbiomes in anaerobic cultures to investigate the metabolism of PCB sulfate to hydroxylated PCBs (OH-PCBs). All microbiomes enzymatically hydrolyzed PCB sulfates. Higher chlorinated PCB sulfates were metabolized more readily. Male mouse microbiomes exhibited more PCB sulfate hydrolysis to OH-PCBs than female mouse microbiomes. Human microbiomes metabolized PCB sulfates to a more considerable extent than mouse microbiomes. They also showed variability in PCB sulfate metabolism, depending on the microbial communities. These findings suggest that the microbiome contributes to PCB metabolism.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Deconjugation of Polychlorinated Biphenyl Sulfates to Hydroxylated PCBs by Anaerobically Cultured Mouse and Human Gut Microbiota. · full record | OpenQuestion