Evidence map›Paper›PMID 40130321›Full record

ArticleEmerging microbes & infections2025

Genomic islands and molecular mechanisms relating to drug-resistance in

Marcela Krutova, Vojtech Kovarovic, Marie Brajerova, Fanny Demay, Jaroslava Zikova, Suhanya Prasad, Anna Soltesova, Elena Novakova, Hanna Pituch, Ed Kuijper and 2 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Influence of COVID-19 on Clinical Outcomes ofAntibiotics (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Frontiers in microbiology · 2026
    Article
  5. Article
  6. EmergingEmerging microbes & infections · 2025
    Article
  7. Dominance of toxigenicFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marcela KrutovaDepartment of Medical Microbiology, Charles University Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Vojtech KovarovicInstitute of Microbiology, The Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic.
Marie BrajerovaDepartment of Medical Microbiology, Charles University Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Fanny DemayInstitute of Microbiology, The Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic.
Jaroslava ZikovaDepartment of Medical Microbiology, Charles University Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Suhanya PrasadDepartment of Medical Microbiology, Charles University Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Anna SoltesovaDepartment of Clinical Microbiology, Unilabs Slovakia Inc., Roznava, Slovakia.
Elena NovakovaDepartment of Microbiology and Immunology, Comenius University Jessenius Faculty of Medicine in Martin, Martin, Slovakia.
Hanna PituchDepartment of Medical Microbiology, Medical University of Warsaw, Warsaw, Poland.
Ed KuijperEuropean Society of Clinical Microbiology and Infectious Diseases (ESCMID) study group for Clostridioides difficile (ESGCD), Basel, Switzerland.
Wiep Klaas SmitsEuropean Society of Clinical Microbiology and Infectious Diseases (ESCMID) study group for Clostridioides difficile (ESGCD), Basel, Switzerland.
Gabriela Balikova NovotnaInstitute of Microbiology, The Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo analyse characteristics of

methodsAntimicrobial susceptibility testing and whole genome sequencing were performed on a selected group of 22 clonally related isolates as determined by multilocus variable-number tandem repeat analysis (n = 509). Heterologous expression and functional analysis of the newly identified methyltransferase were performed.

resultsCore genome multilocus sequence typing found 10-37 allele differences. All isolates were resistant to fluoroquinolones (

conclusionsMultidrug-resistant

Indexed as

Anti-Bacterial AgentsClostridioides difficileClostridium InfectionsDrug Resistance, BacterialDrug Resistance, Multiple, BacterialGenomic IslandsBacterial ProteinsCzech RepublicHumansMethyltransferasesMicrobial Sensitivity TestsMultilocus Sequence TypingPolandRibotypingWhole Genome SequencingAnti-Bacterial AgentsBacterial ProteinsMethyltransferasesClostridioides difficile infectionepidemiologymacrolide resistance methyltransferasewhole genome sequencing

Identifiers

PMID40130321
PMCPMC11983580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.