Observational studyStroke2025
General Anesthesia Versus Conscious Sedation in Thrombectomy Patients With Low NIHSS Anterior Circulation Stroke.
Observational study in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Thrombolysis in Cerebral Infarction (TICI) 2b Versus TICI 3 Reperfusion in Stroke Patients with Mild Symptoms.Clinical neuroradiology · 2026Article
- Outcomes of emergency conversion to general anesthesia during thrombectomy for anterior circulation stroke.Scientific reports · 2026Observational
- Navigating Diagnostic Uncertainty: A Case Report on Anesthetic Management of Mechanical Thrombectomy in a Patient With Occult Fibromuscular Dysplasia.Case reports in anesthesiology · 2026Article
- Current perspective in acute ischemic stroke: net water uptake and imaging-guided selection as bridges to personalized, tissue-based care.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe optimal anesthetic approach for patients with acute ischemic stroke with large vessel occlusion but low National Institutes of Health Stroke Scale receiving mechanical thrombectomy remains unclear. We aimed to evaluate the association of anesthetic strategies with procedural and clinical outcomes, hypothesizing that conscious sedation/local anesthesia (CS/LA) may offer a more favorable risk-benefit ratio than general anesthesia (GA).
methodsMulticenter cohort study screening all thrombectomy patients prospectively enrolled in GSR-ET (German Stroke Registry-Endovascular Treatment) across 25 centers between 2015 and 2021. Patients with an admission National Institutes of Health Stroke Scale score of <6 and large vessel occlusion in the anterior circulation underwent 1:1 propensity score matching by their anesthetic strategy during mechanical thrombectomy (CS/LA versus GA). Outcome measures were an excellent functional outcome (modified Rankin Scale score of 0-1 at 90 days) and successful recanalization (modified Thrombolysis in Cerebral Infarction score of 2b-3).
resultsOf 13 082 thrombectomy cases, 814 had a National Institutes of Health Stroke Scale <6, of whom 36% received CS/LA and 64% received GA. Before matching, CS/LA patients were less often male (46% versus 54%;
conclusionsIn thrombectomy patients with minor stroke, the rate of successful recanalization was comparable between CS/LA and GA. However, our results suggest a more favorable risk-benefit ratio of CS/LA, with an increased rate of excellent functional outcomes.
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