ArticleFrontiers in behavioral neuroscience2025
Low-dose proton induced genetic alteration in cingulate cortex and declined its relevant cognitive function in behaviors.
Article in Frontiers in behavioral neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Environmental radiation poses health risks to the central nervous system (CNS) as well as the internal organs. While the technology for managing radiation has improved, the effects of low-dose radiation in the long term are still considered as a health-related risky factor. The clinical and space radiation studies suggested cognitive threat from proton, but the inconsistent behavioral responses to low-dose proton made their cognitive effects elusive. Here, we examined the low-dose proton-induced functional changes by measuring genetic and behavioral responses. Total 54 mice (C57BL/6, 7 weeks, males) were used for this study. The genetic effects were tested using the brain tissue (cingulate cortex, CC), one of core regions for cognition, and the behavioral responses were evaluated by open field (OFT) and radial maze tests (RMT). In 4 weeks after irradiation, all genes (HSPA, GFAP, MBP, NEFL, NEFM) showed peak inflammatory responses (
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