Evidence map›Paper›PMID 40130169›Full record

ArticleConditioning medicine2024

The Potential of Chronic Remote Ischemic Conditioning in Cerebral Small Vessel Disease.

David C Hess, Askiel Bruno, Mohammad B Khan, Pradip Kamat, Rolf Ankerlund Blauenfeldt, Janne Kaergard Mortensen, Grethe Andersen, Wenbo Zhao, Xunming Ji

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Conditioning medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David C HessDepartment of Neurology, Medical College of Georgia, Augusta University.
Askiel BrunoDepartment of Neurology, Medical College of Georgia, Augusta University.
Mohammad B KhanDepartment of Neurology, Medical College of Georgia, Augusta University.
Pradip KamatDepartment of Neurology, Medical College of Georgia, Augusta University.
Rolf Ankerlund BlauenfeldtDepartment of Neurology, Aarhus University Hospital and Clinical Medicine, Aarhus University, Aarhus, Denmark.
Janne Kaergard MortensenDepartment of Neurology, Aarhus University Hospital and Clinical Medicine, Aarhus University, Aarhus, Denmark.
Grethe AndersenDepartment of Neurology, Aarhus University Hospital and Clinical Medicine, Aarhus University, Aarhus, Denmark.
Wenbo ZhaoDepartment of Neurology, Xuanwu Hospital, Capitol Medical University, Beijing, China.
Xunming JiDepartment of Neurology, Xuanwu Hospital, Capitol Medical University, Beijing, China.

Funding

Augusta SPAN 2U01NS130590 · NINDS · AUGUSTA UNIVERSITY · PI DHANDAPANI, KRISHNAN M., HESS, DAVID C. · 2023 to 2025
$1.8M
Targeting RBC dysfunction in VCIDRF1NS122863 · NINDS · AUGUSTA UNIVERSITY · PI HESS, DAVID C. · 2021 to 2021
$1.6M
Rheoerythrocrine dysfunction in stroke and remote ischemic conditioning (REDS)R01NS112511 · NINDS · AUGUSTA UNIVERSITY · PI HESS, DAVID C. · 2020 to 2023
$1.3M
Targeting RBC dysfunction in VCIDR01NS122863 · NINDS · AUGUSTA UNIVERSITY · PI HESS, DAVID C. · 2024 to 2025
$1.0M
NINDS NIH HHS R01 NS112511NINDS NIH HHS R01 NS122863NINDS NIH HHS RF1 NS122863NINDS NIH HHS U01 NS130590
6 · The paper itself

Abstract

Chronic remote ischemic conditioning (C-RIC) is the month-long or more intervention of RIC. C-RIC has shown promise in a large randomized clinical trial in intracranial atherosclerotic stenosis (ICAS) to reduce the risk of stroke. C-RIC has the potential to reduce cognitive impairment in cerebral small vessel disease (cSVD). C-RIC is effective in a preclinical model of vascular cognitive impairment and dementia (VCID), the bilateral carotid stenosis model in mice, at reducing cognitive impairment, and white matter damage. C-RIC is safe and shows promise in pilot clinical trials of cSVD. In cohort studies, physical exercise is effective at preventing stroke in ICAS and in slowing the progression of cognitive decline in cSVD. C-RIC shares common mechanisms with physical exercise and is an attractive therapy for cSVD. Dosing and compliance are two issues that need to be resolved before large phase II-III trials in cSVD can be optimized.

Indexed as

BiomarkersCerebral small vessel diseaseClinical trialIntracranial atherosclerotic stenosisRemote ischemic conditioning

Identifiers

PMID40130169
PMCPMC11932697

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.