ReviewCureus2025
Adverse Effects of Excessive Folic Acid Consumption and Its Implications for Individuals With the Methylenetetrahydrofolate Reductase C677T Genotype.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Effects of Dietary Folic Acid Supplementation on Productive Performance, Egg Quality, Flavor, and Folate Species Deposition in Laying Hens.Animals : an open access journal from MDPI · 2026Article
- Optimisation of Micronutrient Supplementation During Pregnancy: Interactions Between Bioactive Compounds, Their Impact on Health, and Regulatory Considerations.Biomolecules · 2026Review
- Folate Receptor Alpha (FRα) and the Developing Brain: From Molecular Function to Neurodevelopmental Outcomes.Molecular neurobiology · 2026Review
- Fortification with folic acid and early human embryo development: lessons from assisted reproduction.Journal of assisted reproduction and genetics · 2025Article
- Transition of CELF2 PAS usage promotes recovery of refractory JDM through alternative splicing regulation of CTSB.Molecular therapy. Nucleic acids · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This scoping review examines the risks of high folic acid supplementation in expectant mothers, particularly those with the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism. While folic acid is essential for DNA synthesis and preventing neural tube defects, excessive intake may pose health risks, especially for individuals with the MTHFR variant. These individuals have a reduced ability to process folic acid, leading to the accumulation of unmetabolized folic acid (UMFA), which is associated with vitamin B12 deficiency, cognitive and psychiatric issues, and adverse pregnancy outcomes. This review emphasizes the importance of monitoring folic acid intake and explores alternative supplements such as 5-MTHF or 5-FTHF, which may mitigate these risks by bypassing MTHFR conversion. Personalized nutrition, considering genetic variations, is crucial for optimizing health and minimizing potential harm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.