ArticleCureus2025
Phlegmasia Cerulea Dolens in a 21-Year-Old Female Patient Following Depo-Provera Injection: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Phlegmasia cerulea dolens (PCD) is a rare and severe form of deep vein thrombosis (DVT) associated with limb ischemia. We present the case of a 21-year-old female patient who presented with lower extremity numbness, pain, and swelling, accompanied by pleuritic chest pain and shortness of breath. She had a recent history of receiving a Depo-Provera shot for birth control. Diagnostic assessments revealed an extensive femoral-to-popliteal DVT and bilateral pulmonary embolisms. The patient underwent a series of interventions, including thrombectomy, catheter-directed thrombolysis, and repeat thrombectomy with venoplasty. She was discharged on anticoagulation therapy and showed favorable outcomes during her hospital stay. This case highlights the potential association between Depo-Provera use and the development of PCD, emphasizing the importance of prompt diagnosis, multidisciplinary management, and follow-up care.
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