ArticleCureus2025
Does Statin Therapy Have a Beneficial Effect on Knee Osteoarthritis?
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Pathological mechanisms of osteoarthritis in the network of geriatric comorbidities: Emerging insights from organs-crosstalk.Journal of orthopaedic translation · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionKnee osteoarthritis (KO) is a major public health issue, that significantly affects patients' quality of life. Metabolic comorbidities, particularly dyslipidemia, have been shown to influence the incidence and progression of KO. Given the potential impact of hypercholesterolemia on disease progression, the hypothesis arises that dyslipidemia treatments, such as statins, may offer a beneficial effect in mitigating KO progression. Objective: This study evaluates the effect of statin therapy on the clinical improvement of knee osteoarthritis (KO), particularly in terms of pain reduction, measured using the Visual Analog Scale (VAS).
methodsA cross-sectional, retrospective, descriptive, and analytical study was conducted at the rheumatology department of the University Hospital Center Hassan II of Fez, between January 2018 and January 2024. Patients diagnosed with symptomatic primary knee osteoarthritis (KO) were recruited from the department's database of rheumatology consultations, and all were regularly followed up within the department. The patients were divided into two groups: Group 1, which received statin therapy, and Group 0, a control group that did not receive statins. The primary outcome was clinical improvement, which was assessed using the Visual Analog Scale (VAS) to measure pain intensity.
resultsA total of 465 patients were included, with 48 (10.3%) receiving statins. A significant clinical improvement in KO was observed in 34 (70.8%) patients in the statin group, compared to 196 (47.1%) patients in the control group (p=0.001). The analysis indicated that statin use was significantly associated with clinical improvement, independent of other demographic and comorbid factors.
conclusionsStatin use may provide benefits in the management of KO, particularly in reducing pain, in addition to conventional symptomatic treatments. These results highlight the need for further prospective research to clarify the mechanisms of action of statins in this condition.
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Registered trials
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