Evidence map›Paper›PMID 40130045›Full record

ArticleWorld journal of clinical oncology2025

Role of octamer transcription factor 4 in proliferation, migration, drug sensitivity, and stemness maintenance of pancreatic cancer cells.

Xue-Ying Shi, Xi-Lan Wang, Jin Zhao, Shi-Hai Yang, Cheng-Hai Zhang

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Article in World journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xue-Ying ShiDepartment of General Surgery, The Third Affiliated Hospital, Inner Mongolia Medical University, Baotou 014010, Inner Mongolia Autonomous Region, China.
Xi-Lan WangDepartment of Gastroenterology, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China.
Jin ZhaoDepartment of General Surgery, The Third Affiliated Hospital, Inner Mongolia Medical University, Baotou 014010, Inner Mongolia Autonomous Region, China. zhaojin20072008@163.com.
Shi-Hai YangDepartment of General Surgery, The Third Affiliated Hospital, Inner Mongolia Medical University, Baotou 014010, Inner Mongolia Autonomous Region, China.
Cheng-Hai ZhangDepartment of General Surgery, The Third Affiliated Hospital, Inner Mongolia Medical University, Baotou 014010, Inner Mongolia Autonomous Region, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPancreatic cancer (PC) is one of the most aggressive malignancies characterized by rapid progression and poor prognosis. The involvement of cancer stem cells (CSCs) and Octamer transcription factor 4 (OCT4) in PC pathobiology is being increasingly recognized.

aimTo investigate the role of OCT4 in pancreatic CSCs and its effect on PC cell proliferation, migration, drug sensitivity, and stemness maintenance.

methodsWe analyzed OCT4 and CD133 expression in PC tissues and cell lines. BxPC-3 cells were used to assess the effects of OCT4 modulation on cellular behavior. Proliferation, migration, and stemness of BxPC-3 cells were evaluated, and the PI3K/AKT/mTOR pathway was examined to gain mechanistic insights.

resultsOCT4 and CD133 were significantly overexpressed in PC tissues. OCT4 modulation altered BxPC-3 cell proliferation, invasion, and stemness, with OCT4 overexpression (OV-OCT4) enhancing these properties and OCT4 interference decreasing them. OV-OCT4 activated the PI3K/AKT/mTOR pathway, which correlated with an increase in PC stem cells (PCSC).

conclusionOCT4 plays a crucial role in PCSCs by influencing the aggressiveness and drug resistance of PC cells, thus presenting itself as a potential therapeutic target.

Indexed as

Cancer stem cellsDrug sensitivityOctamer transcription factor 4Pancreatic cancerProliferationStemness

Identifiers

PMID40130045
PMCPMC11866075

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