Evidence map›Paper›PMID 40129897›Full record

ArticleNeurotrauma reports2025

A Small-Molecule TrkB/TrkC Ligand Promotes Neurogenesis and Behavioral Recovery Following Traumatic Brain Injury.

Jian Shi, Tao Yang, Yibing Li, Lily Zhong, Frank M Longo, Stephen M Massa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jian ShiDepartment of Neurology, San Francisco Veterans Affairs Health Care System and University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-7961-8545
Tao YangDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA.
Yibing LiDepartment of Neurology, San Francisco Veterans Affairs Health Care System and University of California, San Francisco, California, USA.
Lily ZhongDepartment of Neurology, San Francisco Veterans Affairs Health Care System and University of California, San Francisco, California, USA.
Frank M LongoDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA.
Stephen M MassaDepartment of Neurology, San Francisco Veterans Affairs Health Care System and University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-0474-4886

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tropomyosin receptor-kinase B (TrkB) and TrkC neurotrophin receptors promote neuronal growth and differentiation during the development and maintenance of structural integrity and plasticity in adult animals. Here, we test the hypotheses that activation of TrkB and TrkC will mitigate neuronal damage and loss, and behavioral deficits induced by traumatic brain injury (TBI). LM22B-10 (C10), a blood-brain barrier permeant small-molecule TrkB/TrkC co-activator, significantly increased proliferation, survival, and enhanced differentiation of neuronal progenitor cells

Indexed as

cell deathcognitive functionLM22B-10neurogenesistraumatic brain injury

Identifiers

PMID40129897
PMCPMC11931105

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.