Evidence map›Paper›PMID 40129718›Full record

ArticleNature physics2024

Flow Physics Guides Morphology of Ciliated Organs.

Feng Ling, Tara Essock-Burns, Margaret McFall-Ngai, Kakani Katija, Janna C Nawroth, Eva Kanso

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Feng LingDepartment of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, California 90089, USA.
Tara Essock-BurnsKewalo Marine Laboratory, University of Hawaii at Manoa, USA.
Margaret McFall-NgaiKewalo Marine Laboratory, University of Hawaii at Manoa, USA.
Kakani KatijaMonterey Bay Aquarium Research Institute, California, USA.
Janna C NawrothDepartment of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, California 90089, USA.
Eva KansoDepartment of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, California 90089, USA.

Funding

The Control of Insect Metabolism through Nutrition-based SymbiosisP20GM125508 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI PATRICIA A COUVILLON · 2018 to 2026
$21.2M
Vibrio fischeri as a Model for Bacterial ColonizationR37AI050661 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI MARGARET J MC FALL-NGAI, Edward G Ruby · 2018 to 2026
$5.4M
Vibrio Virulence Determinants in a Benign ColonizationR01OD011024 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MC FALL-NGAI, MARGARET J, RUBY, EDWARD G · 2012 to 2020
$3.9M
Quantitative analysis of mucociliary clearance in airway ciliopathiesR01HL153622 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KANSO, EVA, RYAN, AMY LEANNE · 2021 to 2024
$1.9M
Vibrio colonization determinants in symbiosisR01GM135254 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI MC FALL-NGAI, MARGARET J, RUBY, EDWARD G · 2020 to 2023
$1.9M
NHLBI NIH HHS R01 HL153622NIAID NIH HHS R37 AI050661NIGMS NIH HHS P20 GM125508NIGMS NIH HHS R01 GM135254NIH HHS R01 OD011024
6 · The paper itself

Abstract

Organs that pump luminal fluids by the coordinated beat of motile cilia are integral to animal physiology. Such organs include the human airways, brain ventricles and reproductive tracts. Although cilia organization and duct morphology vary drastically in the animal kingdom, ducts are typically classified as carpet or flame designs. The reason behind the appearance of these two different designs and how they relate to fluid pumping remain unclear. Here, we demonstrate that two structural parameters - lumen diameter and cilia-to-lumen ratio - organize the observed duct diversity into a continuous spectrum that connects carpets to flames across all animal phyla. Using a unified fluid model, we connect carpet and flame designs to flow rate and pressure generation. We propose that convergence of ciliated organ designs follows functional constraints rather than phylogenetic distance, along with universal design rules for ciliary pumps.

Identifiers

PMID40129718
PMCPMC11932703

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.