Evidence map›Paper›PMID 40129644›Full record

ArticleRSC advances2025

Permeation dynamics of microemulsions according to the amount of deep eutectic solvent when applied to the stratum corneum.

Shotaro Shinoda, Mina Tanigawa, Mina Sakuragi

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shotaro ShinodaFaculty of Engineering, Department of Nanoscience, Sojo University 4-22-1 Ikeda, Nishi-ku Kumamoto City 860-0082 Japan d08b0101@nano.sojo-u.ac.jp.
Mina TanigawaFaculty of Engineering, Department of Nanoscience, Sojo University 4-22-1 Ikeda, Nishi-ku Kumamoto City 860-0082 Japan d08b0101@nano.sojo-u.ac.jp.
Mina SakuragiFaculty of Engineering, Department of Nanoscience, Sojo University 4-22-1 Ikeda, Nishi-ku Kumamoto City 860-0082 Japan d08b0101@nano.sojo-u.ac.jp.ORCID https://orcid.org/0000-0002-6362-3673

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep eutectic solvents (DESs) can enhance the penetration of drug carriers in transdermal drug delivery systems. Previously, we showed that terpene-based DESs substantially enhance the penetration of drug carriers but cause skin damage. To retain the penetration-enhancing properties of DESs while mitigating their adverse effects on the skin, we incorporated small amounts of terpene-based DESs into the oil phase, formulating water-in-oil-type microemulsions (MEs). Stratum corneum (SC) lipid layers, which are sensitive to hydration levels, exhibit changes in spacing and regularity when interacting with DESs. Furthermore, DESs disrupt the lipid structure

Identifiers

PMID40129644
PMCPMC11931507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.