ArticleBurns & trauma2025
Zn ion-incorporated injected hydrogels with reactive oxygen species and glucose scavenging capacity for diabetic wound healing.
Article in Burns & trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Iron, Copper, and Zinc Dyshomeostasis in Cardiovascular and Cerebrovascular Diseases: Redox Mechanisms, Evidence Levels, and Translational Prospects.International journal of molecular sciences · 2026Review
- A Review on Recent Progress and Clinical Translation of Self-Assembled Hydrogels in Diabetic Wound Repair.International journal of nanomedicine · 2026Review
- Copper tannic acid coordination nanosheet as a potent in-situ antibiotic sustained-release carrier for chronic osteomyelitis.Journal of materials science. Materials in medicine · 2025Article
- Multifunctional Metal Composite Hydrogels for Diabetic Wound Therapy.Gels (Basel, Switzerland) · 2025Review
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Authors and funding
8 authors.
Funding
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Abstract
Background: Patients with diabetic wounds often experience challenges in the repair process, owing to increased concentration of glucose and reactive oxygen species (ROS). In addition, high glucose levels usually result in bacterial infections, which in turn worsen wound healing. This study aims to develop a multifunctional hydrogel with integrated antibacterial activity, ROS scavenging, and glucose-responsive properties to accelerate healing of infected diabetic wounds. Methods: A Zn ion-incorporated injected hydrogel was prepared using 4-carboxyphenylboronic acid-modified gelatine, tannic acid, and zinc ions. The spectra were detected using a Fourier transform infrared spectrometer and surface morphologies of hydrogels were obtained using a scanning electron microscopy. The release behavior of Zn ions was investigated using an inductively coupled plasma mass spectrometry instrument. To evaluate the antimicrobial properties of the GPT and GPT@Zn hydrogels, strains of Results: The results show that the hydrogels are injectable and have self-healing properties. Moreover, borate ester bonds are formed in the hydrogels, which are responsive to H Conclusions: This study provides a novel treatment strategy for diabetic wound healing by constructing Zn ion-incorporated injected hydrogels with reactive oxygen species and glucose-scavenging capacity.
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