Evidence map›Paper›PMID 40129423›Full record

SynthesisJournal of oral & facial pain and headache2025

Pseudogout of the temporomandibular joint: a case report with systematic literature review.

Matteo Val, Mirko Ragazzo, Anna Colonna, Marco Ferrari, Edoardo Ferrari Cagidiaco, Daniele Manfredini, Luca Guarda Nardini

Abstract readSystematic ReviewCase Reports
In one paragraph

Synthesis in Journal of oral & facial pain and headache, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. A Case of Pseudogout in an Adolescent on Isotretinoin.Case reports in rheumatology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matteo ValDepartment of Biomedical Technologies, School of Dental Medicine, University of Siena, 53100 Siena, Italy.
Mirko RagazzoUnit of Oral and Maxillofacial Surgery, Ca'Foncello Hospital, 31100 Treviso, Italy.
Anna ColonnaDepartment of Biomedical Technologies, School of Dental Medicine, University of Siena, 53100 Siena, Italy.
Marco FerrariDepartment of Biomedical Technologies, School of Dental Medicine, University of Siena, 53100 Siena, Italy.
Edoardo Ferrari CagidiacoDepartment of Biomedical Technologies, School of Dental Medicine, University of Siena, 53100 Siena, Italy.
Daniele ManfrediniDepartment of Biomedical Technologies, School of Dental Medicine, University of Siena, 53100 Siena, Italy.
Luca Guarda NardiniUnit of Oral and Maxillofacial Surgery, Ca'Foncello Hospital, 31100 Treviso, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCalcium pyrophosphate dihydrate deposition disease (CPPD) is a metabolic disease resulting in acute arthritis. CPPD often affects joints containing fibrocartilage. The purpose of this review is to examine the clinical presentations, prevalence, and treatment modalities associated with CPPD when it affects the temporomandibular joint (TMJ).

methodsA search, following PRISMA guideline, was conducted in various electronic databases (PubMed, Scopus, Web of Science) to find relevant studies about CPPD in the temporomandibular joint. The search spanned from 01 January 1980, to 31 January 2024. A case report was also presented.

resultsA systematic review of literature identified 64 papers, reaching a total of 74 cases of CPPD of the temporomandibular joint TMJ. CPPD is a condition that typically affects middle-aged or older patients, with an average age of around 60 at the time of diagnosis. Females are affected more frequently than males. Most cases involve unilateral TMJ involvement, and common symptoms include pain, reduced mouth opening, and swelling. Different papers also describe severe stages of the invasion of muscles, parotid gland, and even brain structure. Surgery has the preferred treatment option for most Authors and is mandatory for late-stage lesions. The recurrence rate is extremely low.

conclusionsCPPD is an uncommon, locally invasive, and typically benign condition that rarely affects the TMJ. Distinguishing CPDD in the TMJ from other neoplasms poses diagnostic challenges. A definitive diagnosis necessitates histological examination and quantitative microanalysis. In our patient, successful excision of CPDD in the TMJ was achieved using an external approach. THE PROSPERO REGISTRATION: PROSPERO number is CRD42024558402.

Indexed as

ChondrocalcinosisTemporomandibular Joint DisordersFemaleHumansMaleTemporomandibular JointCalcium pyrophosphate dihydrate deposition diseaseEpidemiologyPseudogoutSystematic reviewTemporomandibular joint

Identifiers

PMID40129423
PMCPMC11934741

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.